A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

Autor: Kwok-Yung Yuen, Shibo Jiang, Xiaohui Zhou, Na-Na Zhang, Yufeng Yu, Yanyan Dai, Yu Meng, Lanying Du, Yuan Li, Lu Lu, Jia-Nan Hao, Qian Wang, Peng Zou, Min Tian, Cheng-Feng Qin, Fei Yu, Yong-Qiang Deng, Jasper Fuk-Woo Chan
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
General Physics and Astronomy
Antibodies
Viral
Virus Replication
Zika virus
Mice
Viral Envelope Proteins
Pregnancy
Interferon
Cricetinae
Chlorocebus aethiops
reproductive and urinary physiology
Mice
Inbred ICR
Multidisciplinary
Zika Virus Infection
Transmission (medicine)
Flow Cytometry
Flavivirus
Female
Antibody
medicine.drug
Science
030106 microbiology
Biology
Antiviral Agents
Article
General Biochemistry
Genetics and Molecular Biology
Cell Line
03 medical and health sciences
medicine
Animals
Humans
Vero Cells
Fetus
Virion
Viral Vaccines
Zika Virus
General Chemistry
Viral membrane
biology.organism_classification
Antibodies
Neutralizing
Virology
Mice
Inbred C57BL
Disease Models
Animal
HEK293 Cells
030104 developmental biology
Microscopy
Fluorescence
Drug Design
Vero cell
biology.protein
Pregnancy
Animal
Peptides
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
ISSN: 2041-1723
Popis: Zika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has spread rapidly to more than 70 countries and territories. However, no specific vaccines or antiviral drugs are currently available to prevent or treat ZIKV infection. Here we report that a synthetic peptide derived from the stem region of ZIKV envelope protein, designated Z2, potently inhibits infection of ZIKV and other flaviviruses in vitro. We show that Z2 interacts with ZIKV surface protein and disrupts the integrity of the viral membrane. Z2 can penetrate the placental barrier to enter fetal tissues and is safe for use in pregnant mice. Intraperitoneal administration of Z2 inhibits vertical transmission of ZIKV in pregnant C57BL/6 mice and protects type I or type I/II interferon receptor-deficient mice against lethal ZIKV challenge. Thus, Z2 has potential to be further developed as an antiviral treatment against ZIKV infection in high-risk populations, particularly pregnant women.
Zika virus (ZIKV) has spread rapidly in recent years and there is a need for antiviral treatments. Here, the authors develop an antiviral peptide, based on the stem region of ZIKV envelope protein, and show that it is safe in pregnant mice and inhibits ZIKV infection in pregnant mice and fetuses.
Databáze: OpenAIRE
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