Sulindac in Established Experimental Diabetes: a Follow-up Study
| Autor: | Douglas W. Zochodne, Andrew P. Mizisin, Paul van der Sloot |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Diabetic neuropathy medicine.medical_treatment Nerve conduction velocity Diabetes Mellitus Experimental Rats Sprague-Dawley Sulindac Internal medicine Diabetes mellitus medicine Animals Enzyme Inhibitors Chemotherapy Aldose reductase business.industry General Medicine Streptozotocin medicine.disease Rats Electrophysiology Disease Models Animal Endocrinology Neurology Neurology (clinical) business Polyneuropathy Follow-Up Studies medicine.drug |
| Zdroj: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 22:198-201 |
| ISSN: | 2057-0155 0317-1671 |
| DOI: | 10.1017/s0317167100039846 |
| Popis: | BackgroundIn two previous studies we have demonstrated prevention of electrophysiological abnormalities of nerve in experimental STZ (streptozotocin)-induced diabetes (ED) of rats using nonsteroidal anti-inflammatory agents: indomethacin and sulindac. Sulindac might benefit ED because it inhibits both cyclo-oxygenase and aldose reductase.MethodsIn this work, we examined whether 1 month of sulindac treatment reversed or improved established biochemical and electrophysiological abnormalities in experimental diabetes of 3 months duration. Sulindac-treated diabetic rats (6.0 mg/kg 5/7 days weekly by gavage) were compared to untreated diabetics, nondiabetic controls and sulindac treated control rats.ResultsDiabetic rats developed slowing of conduction velocity in caudal sensory, sural sensory, caudal motor and sciatic tibial motor fibers. Sulindac improved caudal motor and, to a lesser extent sural sensory conduction but not caudal sensory or sciatic tibial motor conduction. Sulindac did not alter sciatic sugars or polyols.ConclusionsSulindac provided modest improvement in some indices of experimental neuropathy in this reversal study, but there was less efficacy than in the preventative study. Reversal paradigms should be examined in all experimental therapies for diabetic neuropathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|