Increased serum levels of brain-derived neurotrophic factor in autism spectrum disorder
| Autor: | Hongguang Chen, Aihong Jiao, Min Wang, Hui Liang, Guangqiang Cui, Tianxia Yu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Brain-derived neurotrophic factor medicine.medical_specialty Chi-Square Distribution Receiver operating characteristic Autism Spectrum Disorder business.industry Brain-Derived Neurotrophic Factor General Neuroscience Area under the curve Enzyme-Linked Immunosorbent Assay Odds ratio medicine.disease Gastroenterology Confidence interval Child Preschool Internal medicine mental disorders Childhood Autism Rating Scale Humans Medicine Autism Female business Chi-squared distribution |
| Zdroj: | NeuroReport. 26:638-641 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/wnr.0000000000000404 |
| Popis: | The aim of this study was to investigate the potential role of brain-derived neurotrophic factor (BDNF) in children with autism spectrum disorders (ASD) by measuring serum circulating levels of BDNF as well as calcium and comparing them with age-matched and sex-matched normal controls. The study included 75 drug-naive ASD children and 75 age-sex-matched healthy children. The concentration of serum BDNF was determined using the enzyme-linked immunosorbent assay method at baseline. Clinical information was collected. The severity of ASD was assessed at admission using the Childhood Autism Rating Scale total score. The results indicated that the mean serum BDNF levels were significantly (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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