The Effects of Cigarette Smoking and Alcohol Consumption on Serum Liver Enzyme Activities: A Dose-Related Study in Men
| Autor: | D Robinson, T P Whitehead, S L Allaway |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male 030213 general clinical medicine Alcohol Drinking Clinical Biochemistry Physiology Aspartate transaminase 030209 endocrinology & metabolism Alcohol digestive system Body Mass Index Nicotine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans Clinical significance Aspartate Aminotransferases Ethanol biology Smoking Age Factors Alanine Transaminase gamma-Glutamyltransferase General Medicine Middle Aged digestive system diseases Liver chemistry Alanine transaminase Biochemistry Toxicity biology.protein Body mass index medicine.drug |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 33:530-535 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/000456329603300607 |
| Popis: | The separate and joint effects of cigarette smoking and alcohol consumption on serum activities of the enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT) and γ-glutamyl transferase (GGT) were investigated in 46775 men attending the BUPA Health Screening Centre in London during the period 1983–1987, after allowing for differences in age, body mass index and exercise level. As expected, all showed a significant positive correlation with alcohol consumption. Cigarette smoking produced a significant increase in GGT activity in all drinking categories bar teetotallers, particularly for those smoking more than 20 cigarettes per day. There were no changes of clinical significance in AST or ALT activities with smoking. We postulate that the combined effects of alcohol and smoking on GGT activity are a result of induction of the enzyme by both alcohol and nicotine. Smoking as well as drinking habits should be taken into account when assessing the significance of an individual's enzyme activities. |
| Databáze: | OpenAIRE |
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