Synthetic glycans control gut microbiome structure and mitigate colitis in mice

Autor: Andrew C. Tolonen, Nicholas Beauchemin, Charlie Bayne, Lingyao Li, Jie Tan, Jackson Lee, Brian M. Meehan, Jeffrey Meisner, Yves Millet, Gabrielle LeBlanc, Robert Kottler, Erdmann Rapp, Chris Murphy, Peter J. Turnbaugh, Geoffrey von Maltzahn, Christopher M. Liu, Johan E. T. van Hylckama Vlieg
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications
Nature communications, vol 13, iss 1
ISSN: 2041-1723
Popis: Relative abundances of bacterial species in the gut microbiome have been linked to many diseases. Species of gut bacteria are ecologically differentiated by their abilities to metabolize different glycans, making glycan delivery a powerful way to alter the microbiome to promote health. Here, we study the properties and therapeutic potential of chemically diverse synthetic glycans (SGs). Fermentation of SGs by gut microbiome cultures results in compound-specific shifts in taxonomic and metabolite profiles not observed with reference glycans, including prebiotics. Model enteric pathogens grow poorly on most SGs, potentially increasing their safety for at-risk populations. SGs increase survival, reduce weight loss, and improve clinical scores in mouse models of colitis. Synthetic glycans are thus a promising modality to improve health through selective changes to the gut microbiome.
Databáze: OpenAIRE
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