Synthesis, Conformation, and Antiviral Activity of 5-Methoxymethyl-2′-deoxycytidine Analogs

Autor:	R.Stephen Reid, Wajdi M. Zoghaib, Shajan Mannala, Guy Tourigny, V. Sagar Gupta
Rok vydání:	2003
Předmět:	Magnetic Resonance Spectroscopy Molecular Structure Stereochemistry viruses Molecular Conformation Deamination Herpesvirus 1 Human General Medicine Nuclear magnetic resonance spectroscopy Crystallography X-Ray Antiviral Agents Deoxycytidine Biochemistry Molecular conformation chemistry.chemical_compound Drug Stability chemistry 5-methoxymethyl-2-deoxycytidine Genetics Molecular Medicine Chromatography High Pressure Liquid
Zdroj:	Nucleosides, Nucleotides and Nucleic Acids. 22:223-238
ISSN:	1532-2335 1525-7770
Popis:	Analogs of 5-methoxymethyl-2'-deoxycytidine, MMdCyd (1) by substitution at N4 were synthesized to impart resistance against deamination. The anti HSV-1 activity and solution conformation of analogs were determined. N4-Butanoyl-MMdCyd (10) was a potent inhibitor of HSV-1 replication while N4-hexanoyl-MMdCyd (11), N4-propanoyl-MMdCyd (9) and N4-acetyl-MMdCyd (8) had good activity against HSV-1 replication. All other analogs were devoid of activity against HSV-1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88fede6d5ce063003a64376204231ee https://doi.org/10.1081/ncn-120019532 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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