Rejection associated with early appearance of donor-reactive antibodies after kidney transplantation treated with plasmapheresis and administration of 15-deoxyspergualin
| Autor: | B. Wikström, L. Weiss, U. Persson, S. Gudmundsson, G. Gannedahl, S. Ohlman, Thomas H. Tötterman, Gunnar Tydén, Erik G. Larsson, Carl-Gustav Groth, Gunnar Tufveson |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Graft Rejection Nephrology medicine.medical_specialty medicine.medical_treatment Urology Guanidines Antibodies Leukocytopenia HLA Antigens Internal medicine Humans Medicine Kidney transplantation Transplantation business.industry Plasmapheresis medicine.disease Kidney Transplantation Surgery Immunosuppressive drug Methylprednisolone Female Anuria medicine.symptom business Immunosuppressive Agents medicine.drug |
| Zdroj: | Transplant International. 5:189-192 |
| ISSN: | 1432-2277 0934-0874 |
| DOI: | 10.1007/bf00336067 |
| Popis: | In two kidney transplant patients, one of whom had panel-reactive antibodies (PRA) before transplantation, a pretransplant negative donor-recipient crossmatch became positive within the 1st week after transplantation. Simultaneously, good graft function deteriorated to a state of anuria. One patient graft biopsy showed a vascular rejection, whilst the other patient biopsy was unrevealing. Both patients were treated with plasmapheresis and a new immunosuppressive drug, 15-deoxyspergualin (DSG). Plasmapheresis was performed for 6 and 9 days, respectively, and DSG was given for 5 days in a dosage of 6 mg/kg body weight per day. One of the patients received methylprednisolone i.v. in addition. During treatment the cross-match became negative and has since remained that way. In both patients the graft function was restored. No adverse effects were seen from the treatment, except for a slight leukocytopenia and thrombocytopenia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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