Effect of obesity on the association between MYL2 (rs3782889) and high-density lipoprotein cholesterol among Korean men
| Autor: | Sang Won Kim, Eo Rin Cho, Yon Ho Jee, Jae Woong Sull |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Myosin Light Chains Genotype Comorbidity 030204 cardiovascular system & hematology Biology Bioinformatics Polymorphism Single Nucleotide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Risk Factors Internal medicine Republic of Korea Odds Ratio Genetics medicine Humans Obesity Alleles Genetic Association Studies Genetics (clinical) Cholesterol Cholesterol HDL Odds ratio Middle Aged medicine.disease 030104 developmental biology Endocrinology chemistry Female Cardiac Myosins Body mass index Biomarkers Pharmacogenetics Lipoprotein |
| Zdroj: | Journal of Human Genetics. 61:405-409 |
| ISSN: | 1435-232X 1434-5161 |
| DOI: | 10.1038/jhg.2015.165 |
| Popis: | High-density lipoprotein (HDL) cholesterol levels are associated with a decreased risk of coronary artery disease. Several genome-wide association studies that have examined HDL cholesterol levels have implicated myosin light chain 2 regulatory cardiac slow (MYL2) as a possible causal factor. Herein, the association between the rs3782889 single-nucleotide polymorphism (SNP) in the MYL2 gene and HDL cholesterol levels was tested in the Korean population. A total of 4294 individuals were included in a replication study with MYL2 SNP rs3782889. SNP rs3782889 in the MYL2 gene was associated with mean HDL cholesterol level (effect per allele, -1.055 mg dl(-1), P=0.0005). Subjects with the CT/CC genotype had a 1.43-fold (range 1.19-1.73-fold) higher risk of an abnormal HDL cholesterol level ( |
| Databáze: | OpenAIRE |
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