Venous thrombolysis by tissue-type plasminogen activator in conjunction with the urokinase-fibrinogen covalent conjugate
| Autor: | Artem D. Petrov, Elena G. Tischenko, Alexander V. Maksimenko, Marina L. Petrova, Vladimir L. Golubykh |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Macromolecular Substances medicine.medical_treatment Bioengineering Fibrinogen Applied Microbiology and Biotechnology Biochemistry Dogs Bolus (medicine) Internal medicine medicine Animals Molecular Biology Urokinase biology Chemistry T-plasminogen activator Fissipedia General Medicine Thrombolysis Thrombophlebitis biology.organism_classification medicine.disease Urokinase-Type Plasminogen Activator Venous thrombosis Endocrinology Tissue Plasminogen Activator Plasminogen activator Biotechnology medicine.drug |
| Zdroj: | Applied Biochemistry and Biotechnology. 61:123-128 |
| ISSN: | 1559-0291 0273-2289 |
| DOI: | 10.1007/bf02785694 |
| Popis: | Conjunctive administration of the tissue-type plasminogen activator (t-PA) and the urokinase-fibrinogen covalent conjugate (UK-Fbg) was studied by the example of venous thrombosis in dogs. Comparing the effect of separate use of the two components, we observed the potentiation of thrombolytic effect induced by an i.v. bolus infusion administration of the tissue-type plasminogen activator (1 and 4 mg, respectively) combined with a bolus administration 15 min after the first injection of the 25,000 IU UK-Fbg. Faster-action and potentiation effects of thrombolysis were observed with the same administration scheme when the t-PA was used as bolus infusion (1 and 1 mg, respectively) combined with a bolus of the 250,000 IU fibrinogen-modified urokinase. The findings indicate an approach to the development of efficient thrombolytic compositions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink