The pharmacological interaction of compounds in ayahuasca: a systematic review
| Autor: | Nige Netzband, Catherine Bird, Simon Ruffell, Allan H. Young, Mario Francisco Juruena |
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| Rok vydání: | 2020 |
| Předmět: |
Psychotherapist
Web of science medicine.drug_class tetrahydroharmine Dimethyltryptamine RC435-571 Tetrahydroharmine B-carboline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Harmine medicine Psychoactive plant Psychiatry Monoamine oxidase inhibitor monoamine oxidase inhibitor Psychoactive drug Ayahuasca 030227 psychiatry Psychiatry and Mental health chemistry Psychology 030217 neurology & neurosurgery medicine.drug ayahuasca |
| Zdroj: | Brazilian Journal of Psychiatry, Issue: ahead, Published: 03 JUL 2020 Brazilian Journal of Psychiatry v.42 n.6 2020 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP UnpayWall ORCID Microsoft Academic Graph PubMed Central Scientific Electronic Library Online-Brazil LAReferencia-Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas DOAJ-Articles Revista Brasileira de Psiquiatria Brazilian Journal of Psychiatry, Vol 42, Iss 6, Pp 646-656 (2020) Brazilian Journal of Psychiatry Brazilian Journal of Psychiatry, Volume: 42, Issue: 6, Pages: 646-656, Published: 03 JUL 2020 |
| ISSN: | 1809-452X 1516-4446 |
| Popis: | Ayahuasca is a South American psychoactive plant brew used as traditional medicine in spiritual and in cultural rituals. This is a review of the current understanding about the pharmacological mechanisms that may be interacting in ayahuasca. Searches were performed using PubMed, PsycINFO, and Web of Science databases and 16 papers were selected. As hypothesized, the primary narrative in existing research revolved around prevention of deamination of N,N-dimethyltryptamine (N,N-DMT, also referred to as DMT) by monoamine oxidase inhibitors (MAOIs) in ayahuasca. Two of the constituents, DMT and harmine, have been studied more than the secondary harmala alkaloids. At present, it is unclear whether the pharmacological interactions in ayahuasca act synergistically or additively to produce psychoactive drug effects. The included studies suggest that our current understanding of the preparation’s synergistic mechanisms is limited and that more complex processes may be involved; there is not yet enough data to determine any potential synergistic interaction between the known compounds in ayahuasca. Our pharmacological understanding of its compounds must be increased to avoid the potential risks of ayahuasca use. |
| Databáze: | OpenAIRE |
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