| Autor: |
Shuaipeng Feng, Jiahong Wang, Xiaoyang Mu, Guanliang Gu, Yufei Wang, Junya Lu, Siling Wang, Qinfu Zhao |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Colloids and Surfaces B: Biointerfaces. 222:113095 |
| ISSN: |
0927-7765 |
| DOI: |
10.1016/j.colsurfb.2022.113095 |
| Popis: |
The over-expressed GSH in tumor microenvironment significantly weakens the lethal reactive oxygen species (ROS) generated by photodynamic therapy (PDT) and catalysis of nanoenzyme. Hence, it is necessary to excavate a versatile and effective vehicle with oxidative stress-enhancement and GSH-depletion capacity to break the redox homeostasis in tumor microenvironment. GO has been reported to possess GSH-depletion and peroxidase (POD)-like capacity. Based on this, PEGylated mesoporous carbon (MC-PEG) was prepared as ICG vehicle to compare with PEGylated graphene oxide (GO-PEG). Excitingly, MC-PEG was found to exhibit three times higher oxidative capacity by POD-like process than GO-PEG, and owned more effective and continuous GSH-depletion capacity to further amplify the oxidative stress. Meanwhile, MC-PEG exhibited better protective effect on the loaded ICG against unwanted light excitation than GO-PEG. Together with the higher photothermal conversion effect, under the NIR light irradiation, MC-PEG could markedly improve the temperature of tumor cells and produce more hydroxyl radical, continuously consume GSH and provide more better protection for ICG compared with GO-PEG, thus further boosting the combination of photothermal and photodynamic effects. The anti-tumor experiment in cell and in-vivo level both validated that ICG/MC-PEG showed better synergistic effect with lower IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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