Glycogen synthase kinase-3β regulates tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis via the NF-κB pathway in hepatocellular carcinoma
Autor: | Huazheng Pan, Jing Lv, Zhaojun Wan, Shihai Liu, Kai Fu, Jun Liang, Qing Sun, Jiao Li |
---|---|
Rok vydání: | 2015 |
Předmět: | |
Zdroj: | Oncology Letters. 10:3557-3564 |
ISSN: | 1792-1082 1792-1074 |
Popis: | Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for its ability to selectively induce apoptosis in malignant cells. However, human hepatocellular carcinoma (HCC) cells display resistance to TRAIL-induced cell death. The present study investigated whether TRAIL-induced apoptosis in HCC cells was enhanced by the administration of an inhibitor of glycogen synthase kinase-3β (GSK-3β) or by short hairpin RNA-mediated inhibition of GSK-3β. The results of the current study demonstrated that inhibition of GSK-3β significantly impairs the expression of the nuclear factor-κB (NF-κB) target genes Bcl-xL and clAP2 in HCC cells (P |
Databáze: | OpenAIRE |
Externí odkaz: |