Glycogen synthase kinase-3β regulates tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis via the NF-κB pathway in hepatocellular carcinoma

Autor:	Huazheng Pan, Jing Lv, Zhaojun Wan, Shihai Liu, Kai Fu, Jun Liang, Qing Sun, Jiao Li
Rok vydání:	2015
Předmět:	Cancer Research Programmed cell death Cell NF-κB Articles Cell cycle Biology chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry Apoptosis GSK-3 Immunology medicine Cancer research biology.protein Tumor necrosis factor alpha Glycogen synthase
Zdroj:	Oncology Letters. 10:3557-3564
ISSN:	1792-1082 1792-1074
Popis:	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known for its ability to selectively induce apoptosis in malignant cells. However, human hepatocellular carcinoma (HCC) cells display resistance to TRAIL-induced cell death. The present study investigated whether TRAIL-induced apoptosis in HCC cells was enhanced by the administration of an inhibitor of glycogen synthase kinase-3β (GSK-3β) or by short hairpin RNA-mediated inhibition of GSK-3β. The results of the current study demonstrated that inhibition of GSK-3β significantly impairs the expression of the nuclear factor-κB (NF-κB) target genes Bcl-xL and clAP2 in HCC cells (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88d2c109b330f6e3560bcfc972fecd9 https://doi.org/10.3892/ol.2015.3803 Zobrazit plný text záznamu Plný text ve formátu PDF