Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study

Autor: Ethan A. Winkler, Allison J. Hricik, Esther L. Yuh, Ramon Diaz-Arrastia, Ava M. Puccio, Kristen Dams-O'Connor, Wayne A. Gordon, David M. Schnyer, Zhiqun Zhang, David O. Okonkwo, Andrew I R Maas, Alex B. Valadka, Pratik Mukherjee, David K. Menon, Tomoo Inoue, Tuhin K. Sinha, Hester F. Lingsma, Shelly R. Cooper, Mary J. Vassar, John K. Yue, Geoffrey T. Manley, Kevin K.W. Wang, Zhihui Yang
Přispěvatelé: Public Health, TRACK-TBI Investigators
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Traumatic
Pathology
glia
medicine.medical_treatment
Pilot Projects
Clinical knowledge
0302 clinical medicine
Brain Injuries
Traumatic
80 and over
Aged
80 and over
Rehabilitation
Plasma samples
Glial fibrillary acidic protein
biology
traumatic brain injury
autoimmunity
Injuries and accidents
Middle Aged
Cohort
Acute Disease
Female
Adult
medicine.medical_specialty
Physical Injury - Accidents and Adverse Effects
Adolescent
Traumatic brain injury
Short Communication
Clinical Sciences
Traumatic Brain Injury (TBI)
03 medical and health sciences
Young Adult
Clinical Research
Internal medicine
Glial Fibrillary Acidic Protein
medicine
Humans
Traumatic Head and Spine Injury
Autoantibodies
Aged
Neurology & Neurosurgery
business.industry
Glasgow Coma Scale
Autoantibody
Neurosciences
biomarkers
medicine.disease
nervous system diseases
Brain Disorders
030104 developmental biology
nervous system
Brain Injuries
Chronic Disease
biology.protein
Neurology (clinical)
Human medicine
business
030217 neurology & neurosurgery
autoantibody
Zdroj: Journal of neurotrauma, vol 33, iss 13
Journal of Neurotrauma, 33(13), 1270-1277. Mary Ann Liebert Inc.
Journal of neurotrauma
ISSN: 0897-7151
1557-9042
Popis: We described recently a subacute serum autoantibody response toward glial fibrillary acidic protein (GFAP) and its breakdown products 5-10 days after severe traumatic brain injury (TBI). Here, we expanded our anti-GFAP autoantibody (AutoAb[GFAP]) investigation to the multicenter observational study Transforming Research and Clinical Knowledge in TBI Pilot (TRACK-TBI Pilot) to cover the full spectrum of TBI (Glasgow Coma Scale 3-15) by using acute (
Databáze: OpenAIRE
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