Role of dopamine D1 and D2 receptors in the micturition reflex in conscious rats
| Autor: | Karl-Erik Andersson, Osamu Ishizuka, Yasuhiko Igawa, Kouichi Kaidoh, Satoshi Seki, Osamu Nishizawa |
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| Rok vydání: | 2000 |
| Předmět: |
Agonist
medicine.medical_specialty Quinpirole medicine.drug_class Urology Urinary Bladder Urination Pharmacology Rats Sprague-Dawley chemistry.chemical_compound Dopamine receptor D1 Dopamine receptor D2 Internal medicine Reflex medicine Remoxipride Animals Receptor SCH-23390 Receptors Dopamine D2 business.industry Receptors Dopamine D1 Drug Synergism Benzazepines Rats Endocrinology chemistry Dopamine Agonists Injections Intravenous Dopamine Antagonists Female 2 3 4 5-Tetrahydro-7 8-dihydroxy-1-phenyl-1H-3-benzazepine Neurology (clinical) business medicine.drug |
| Zdroj: | Neurourology and Urodynamics. 20:105-113 |
| ISSN: | 1520-6777 0733-2467 |
| DOI: | 10.1002/1520-6777(2001)20:1<105::aid-nau12>3.0.co;2-9 |
| Popis: | To clarify the role of dopamine D1 and D2 receptors in the volume-induced micturition reflex, conscious, female rats were investigated cystometrically before and after intravenous administration of SKF 38393 (a selective D1 receptor agonist), SCH 23390 (a selective D1 receptor antagonist), quinpirole (a selective D2 receptor agonist), and remoxipride (a selective D2 receptor antagonist). The effect of quinpirole was also investigated in the presence of remoxipride. Intravenous administration of SKF 38393 (0.01-3.0 mg/kg) did not affect any cystometric parameters investigated. On the other hand, SCH 23390 (0.1-1.0 mg/kg i.v.) reduced bladder capacity and micturition volumes and increased the micturition pressure in a dose-dependent manner. Quinpirole (0.01-0.1 mg/kg) given intravenously, dose-dependently decreased bladder capacity and micturition volumes. Pre-treatment with remoxipride (1.0 mg/kg i.v.) significantly attenuated the effect of quinpirole (0.1 mg/kg i.v.). Remoxipride (0.1-1.0 mg i.v.) itself did not cause any significant changes in the cystometric parameters. These results suggest that in conscious rats, D1 receptors tonically inhibit the micturition reflex and that D2 receptors are involved in facilitation of the micturition reflex. It may be speculated that detrusor hyperreflexia associated with Parkinson's disease results from activation failure of D1 receptors and that administration of D2 receptor agonists might worsen the condition. |
| Databáze: | OpenAIRE |
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