Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

Autor:	Vijayakumar Badathala, Kondaiah Seku, Mahesh Kancherla, Kishore Kumar K, Anil Kumar Yamala
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Silver lcsh:Analytical chemistry General Physics and Astronomy 010402 general chemistry 01 natural sciences General Biochemistry Genetics and Molecular Biology Coordination complex Metal lcsh:Chemistry Crystallinity Transition metal General Materials Science Moxifloxacin-metal complexes General Environmental Science chemistry.chemical_classification Aqueous solution lcsh:QD71-142 010405 organic chemistry Chemistry Ligand Biological activity Structure General Chemistry 0104 chemical sciences Octahedron lcsh:QD1-999 visual_art visual_art.visual_art_medium Gold Antibacterial activity Nuclear chemistry
Zdroj:	Journal of Analytical Science and Technology, Vol 9, Iss 1, Pp 1-13 (2018)
ISSN:	2093-3371
DOI:	10.1186/s40543-018-0147-z
Popis:	Background The drug-metal complexes are used to control the growth of pathogens and parasites which are harmful to humans. Moxifloxacin (MOX) is a new fourth generation 8- methoxy fluoroquinolone. Its chemical name is [1-cyclopropyl-7-(S,S)-2,8-diazabicyclo(4.3.0)- non-8-yl-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3-quinoline carboxylic acid hydrochloride]. Many researchers have reported Moxifloxacin-metal complexes with transition metals and studied their biological applications. We have synthesized novel moxifloxacin- Au(III) and Ag(I) metal complexes ([Au(MOX) 2 (Cl) 2 ].2H 2 O and [Ag (MOX) 2 ].2H 2 O), characterized, and found their biological activities. Methods Moxifloxacin- Au(III) and Ag(I) metal complexes were prepared by adding corresponding aqueous solutions of Au(III) and Ag(I) metal salts to methanolic solution of Moxifloxacin. These metal complexes were characterized by physio-chemical techniques like UV-Vis, 1 H- NMR, FTIR, XRD, DSC, TGA, SEM and microanalytical data. The disc diffusion method was used to study the antibacterial activity of the Moxifloxacin-metal complexes. Results The structural assessment of these complexes has been carried out based on physio- chemical and spectroscopic methods. The powder X-ray diffraction data of the metal complexes revealed moderate crystallinity. SEM analysis confirms that [Ag(MOX) 2 ].2H 2 O complex has small rods like morphology whereas [Au(MOX) 2 (Cl) 2 ].2H 2 O has well crystalline rods like morphology. The results from DSC of moxifloxacin- Au(III) and Ag(I) metal complexes revealed the interaction between the drug and metals. Further, Au & Ag moxifloxacin metal complexes have shown significant antibacterial activity against gram-positive and gram-negative bacteria. Conclusions The spectral and analytical results clearly confirmed the coordination chemistry of Au (III) and Ag (I) Moxifloxacin metal complexes. The IR, electronic transition and elemental data led to the conclusion that the geometry of the complex of Au(III) is octahedral and that of Ag (I) complex is tetrahedral. The [Ag(MOX) 2 ].2H 2 O complex has showed good antibacterial activity compared to [Au (MOX) 2 (Cl) 2 ].2H 2 O metal complex. The antibacterial activity studies indicate the metal complexes have more biological activity than free ligand.
Databáze:	OpenAIRE
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