Targeting drug delivery and efficient lysosomal escape for chemo-photodynamic cancer therapy by a peptide/DNA nanocomplex
| Autor: | Qiusheng Wang, Ziyun He, Hai Zhu, Wenxia Gao, Nan Zhang, Jing Li, Jianqin Yan, Bin He, Xueting Ye |
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| Rok vydání: | 2022 |
| Předmět: |
Drug Carriers
Photosensitizing Agents Porphyrins Light Singlet Oxygen Biomedical Engineering Antineoplastic Agents 3T3 Cells DNA General Chemistry General Medicine Aptamers Nucleotide Nanostructures Mice Drug Therapy Photochemotherapy Doxorubicin Animals Humans General Materials Science Lysosomes Peptides HeLa Cells |
| Zdroj: | Journal of Materials Chemistry B. 10:438-449 |
| ISSN: | 2050-7518 2050-750X |
| DOI: | 10.1039/d1tb02441h |
| Popis: | A peptide/DNA nanocomplex was developed for the targeted delivery of chemotherapeutics and photosensitizers to cancer cells for efficient combination therapy. The chemotherapeutic drug doxorubicin (DOX) and the photosensitizer 5,10,15,20-tetra-(1-methylpyridine-4-yl)-porphyrin (TMPyP4) were physically incorporated by an aptamer (AS1411)-modified tetrahedral DNA nanostructure, where the tetrahedral DNA and aptamer-induced G-quadruplex provide binding sites of DOX and TMPyP4. The co-loaded 3A-TDN/DT displayed a targeted uptake by HeLa cancer cells through the high affinity and specificity between AS1411 and nucleolin, a protein overexpressed on many types of cancer cells. A polycationic polymer, mPEG-PAsp(TECH), was synthesized to complex with the DNA nanostructure to efficiently escape from lysosomes |
| Databáze: | OpenAIRE |
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