Purine metabolism in women with primary gout
| Autor: | Carlos Pérez de Ayala, Felícitas A. Mateos, Juan G. Puig, Rosa J. Torres, Antonio Gil, Eugenio de Miguel, Maria Eugenia Miranda |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Purine medicine.medical_specialty Gout Xanthine Excretion chemistry.chemical_compound Sex Factors Internal medicine medicine Humans Prospective Studies Purine metabolism Hypoxanthine Aged Creatinine business.industry nutritional and metabolic diseases General Medicine Middle Aged medicine.disease Uric Acid Endocrinology chemistry Purines Hypoxanthines Xanthines Uric acid Female business |
| Zdroj: | The American Journal of Medicine. 97:332-338 |
| ISSN: | 0002-9343 |
| Popis: | purpose: Uncontrolled studies have shown that women with gout have higher serum urate concentrations and similar or lower urinary uric acid excretion rates than do men with gout. These observations suggest a more defective tubular transport of uric acid in women than in men with gout. In this prospective study we assessed purine metabolism in women with primary gout under controlled conditions. We also examined whether there are sex-related differences in plasma and urinary purine concentrations among patients with primary gout. subjects and methods: Ten women with crystal-proved primary gout and normal serum creatinine levels (below 116 mmol/L) were studied while they were on a purine-restricted diet and taking no medications known to influence uric acid metabolism. For comparison, 20 men with primary gout and 10 women without gout, matched for age, race, and body mass index, were studied under the same conditions. In each subject, plasma and 24-hour urinary uric acid, hypoxanthine, and xanthine concentrations were measured. The mean of three consecutive determinations for plasma purines and five for urinary purines was used. Standard formulas were used to calculate the renal clearances and the fractional excretion of purines. results: Mean plasma urate, hypoxanthine, and xanthine levels were significantly higher in women patients with primary gout compared with normal women (P |
| Databáze: | OpenAIRE |
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