Acupuncture for the prevention of radiation-induced xerostomia in patients with head and neck cancer
Autor: | Fábio de Abreu Alves, Dante Antônio Migliari, Celso Augusto Lemos Júnior, Fabio do Prado Florence Braga |
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Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Adult
Male medicine.medical_specialty Visual analogue scale medicine.medical_treatment Acupuncture Therapy Gastroenterology Xerostomia Salivary Glands Statistical significance Major Salivary Gland Internal medicine Surveys and Questionnaires medicine Acupuncture Humans General Materials Science Radiation Injuries Aged Aged 80 and over Analysis of Variance Salivary gland Radiotherapy business.industry Head and neck cancer Middle Aged medicine.disease Surgery Radiation therapy lcsh:RK1-715 medicine.anatomical_structure Treatment Outcome Head and Neck Neoplasms lcsh:Dentistry Female Analysis of variance business Salivation |
Zdroj: | Brazilian Oral Research, Volume: 25, Issue: 2, Pages: 180-185, Published: APR 2011 Brazilian Oral Research v.25 n.2 2011 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO Brazilian Oral Research, Vol 25, Iss 2, Pp 180-185 (2011) |
Popis: | The aim of this study was to evaluate the effectiveness of acupuncture in minimizing the severity of radiation-induced xerostomia in patients with head and neck cancer. A total of 24 consecutive patients receiving > 5000 cGy radiotherapy (RT) involving the major salivary glands bilaterally were assigned to either the preventive acupuncture group (PA, n = 12), treated with acupuncture before and during RT, or the control group (CT, n = 12), treated with RT and not receiving acupuncture. After RT completion, clinical response was assessed in all patients by syalometry, measuring the resting (RSFR) and stimulated (SSFR) salivary flow rates, and by the visual analogue scale (VAS) regarding dry mouth-related symptoms. Statistical analyses were performed with repeated-measures using a mixed-effect modeling procedure and analysis of variance. An alpha level of 0.05 was accepted for statistical significance. Although all patients exhibited some degree of impairment in salivary gland functioning after RT, significant differences were found between the groups. Patients in the PA group showed improved salivary flow rates (RSFR, SSFR; p < 0.001) and decreased xerostomia-related symptoms (VAS, p < 0.05) compared with patients in the CT group. Although PA treatment did not prevent the oral sequelae of RT completely, it significantly minimized the severity of radiation-induced xerostomia. The results suggest that acupuncture focused in a preventive approach can be a useful therapy in the management of patients with head and neck cancer undergoing RT. |
Databáze: | OpenAIRE |
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