Responses of nonhuman primates to a polybrominated biphenyl mixture
| Autor: | D A Barsotti, L. K. Lambrecht, J R Allen |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Polybrominated biphenyl Health Toxicology and Mutagenesis Polybrominated Biphenyls Physiology Body weight Internal medicine medicine Animals Birth Weight Flame Retardants Adult female Gastric emptying Chemistry Biphenyl Compounds Body Weight Public Health Environmental and Occupational Health Haplorhini Macaca mulatta humanities Menstruation Biphenyl compound Cholesterol Endocrinology Animals Newborn Gastric Emptying Gastric Mucosa Fertilization bacteria Female Research Article |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | In a series of experiments, rhesus monkeys have been given in their diets 0.3, 1.5, and 25 ppm of a commercial polybrominated biphenyl (PBB) (as FireMaster FF-1). The seven adult female monkeys receiving 0.3 ppm PBB have been on the treatment regime for 15 months and have consumed over 22 mg of PBB. During the initial 6 months of exposure, they lost weight and 2 of the animals develop sterile abscesses. At 6 months, 4 of the 7 animals had flattened and lengthened serum progesterone peaks. This change was correlated with an increase in length of their menstrual cycles. After 6 months of PBB exposure, the animals were bred. Two of the 7 animals showed excessive and prolonged implantation bleeding. Two abortions and 5 live births were recorded. All of the experimental infants were smaller than the controls at birth. The animals receiving a diet containing 1.5 ppm PBB for 36 weeks (total intake 70 mg) have shown a moderate weight loss and decrease in serum cholesterol. Similar changes have also been recorded in the group given the 25 ppm PBB diet for 14 weeks (approximately 500 mg total intake). In addition, these animals have also developed a hyperplastic gastritis. Images FIGURE 1. FIGURE 2. FIGURE 3. FIGURE 4. FIGURE 5. |
| Databáze: | OpenAIRE |
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