Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100
Autor: | Emilie Gagniere, Noureddine Lebaz, Fabrice Ofridam, Denis Mangin, Abdelhamid Elaissari |
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Přispěvatelé: | Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique (LAGEPP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS) |
Rok vydání: | 2020 |
Předmět: |
Polyethylenimine
Materials science Aqueous solution Polymers and Plastics Polyacrylic acid pH-sensitive polymers 02 engineering and technology [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Polyvinyl alcohol Polyelectrolyte 0104 chemical sciences chemistry.chemical_compound [CHIM.POLY]Chemical Sciences/Polymers chemistry Chemical engineering Zeta potential [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering Particle size 0210 nano-technology |
Zdroj: | Polymers for Advanced Technologies Polymers for Advanced Technologies, Wiley, 2020, 31 (6), ⟨10.1002/pat.4856⟩ |
ISSN: | 1099-1581 1042-7147 |
DOI: | 10.1002/pat.4856 |
Popis: | International audience; Interpolyelectrolyte complexes or polyplexes can be seen as interesting alternatives in the purpose of active ingredients encapsulation. Working on polymethylmethacrylate derivatives with special focus on controlled oral drug delivery, the influence of charged polyelectrolytes (polyacrylic acid, polyethylenimine, amino-dextran) and non-charged ones (polyvinyl alcohol , dextran 40, Pluronic F68) has been investigated on the precipitation of two pH-sensitive Eudragit polymers namely L100 and E100. Moreover, the possibility of preparing polyplexes involving the two polymethylmethacrylate derivatives with different charged and non-charged secondary polyelectrolytes has been studied. The obtained dispersions have been characterized in terms of mean particle size, size distribution, zeta potential and morphology. Direct precipitation of Eudragit L100 by medium acidification in a batch process and in presence of polyethylenimine allowed the production of particles with a narrow size distribution. The mean size was around 200 nm. In this case, the zeta potential was found to be +45 mV at pH=7 in 1 mM aqueous NaCl solution and the produced suspension was stable in time since no aggregation and then no sedimentation has been observed. A precipitation pH of 8.16 allows us to suggest the preparation of a polyplex based on Eudragit L100 and polyethylenimine. In contrary, polyvinyl alcohol has shown ability to induce an increase in * . |
Databáze: | OpenAIRE |
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