| Popis: |
The mechanism underlying the reported hepatotoxicity of gasoline fumes in experimental studies still remains unclear. In this study, we present insights into the mechanism underlying hepatotoxicity of gasoline fumes in 72 male albino rats. The rats were randomized into six groups. Group I (control) was exposed to distilled water while groups II, III, IV, V and VI were daily exposed to gasoline fumes for 1, 3, 5, 7 and 9 hours respectively for 10 weeks. Serum hepatic and oxidative stress markers, activity of the mixed function oxygenase (MFO) and membrane-bound ATPase enzymes in the liver as well as histopathological examination of the organ were monitored. Gasoline compositions and its residues in the liver were quantified with Gas Chromatography Mass Spectrometry. Significant (p |
