The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation

Autor: Charman, T., Loth, Eva, Tillmann, Julian, Crawley, Daisy, Wooldridge, C., Goyard, David, Ahmad, Jumana, Auyeung, Bonnie, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen,Simon, Baumeister, Sarah, Beckmann, Christian, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, Brammer, Michael, Brandeis, Daniel, Brogna, Claudia, De Bruijn, Y., Chakrabarti,B., Cornelissen, Ineke, Acqua, Flavio Dell, Dumas, G., Durston, Sarah, Ecker,C., Faulkner, J., Frouin, Vincent, Garces, Pilar, Ham, Lindsay M., Hayward, Hannah, Hipp, Joerg, Holt, R. J., Isaksson, Johan, Johnson, Mark H., Jones, Emily J. H., Kundu, Prantik, Lai,Meng-Chuan, D'Ardhuy, X. L., Lombardo, Michael V., Lythgoe, David J., Mandl, Rene, Mason, Luke, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan J., Persico, Antonio M., Ruggeri, B., Ruigrok,Amber N. V., Sabet, Jessica, Sacco, Roberto, Caceres, Antonia San Jose, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams,Steven C. R., Zwiers, Marcel P., Spooren, Will, Murphy,Declan G. M., Buitelaar, Jan K., Lombardo,Michael V.
Přispěvatelé: Institute of Psychiatry, Psychology & Neuroscience, King's College London, King‘s College London, Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, University of Edinburgh, Autism Research Centre and Section of Developmental Psychiatry, University of Cambridge [UK] ( CAM ), University Medical Center [Utrecht], Universität Heidelberg [Heidelberg], Medizinische Fakultät Mannheim, Radboud University Medical Center [Nijmegen], Karolinska Institutet [Stockholm], Génétique humaine et Fonctions cognitives - Human Genetics and Cognitive Functions, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM ), University of Reading ( UOR ), Goethe-University Frankfurt am Main, Roche Pharma Research and Early Development [Basel] ( pRED ), F. Hoffmann-La Roche [Basel], Uppsala University, Centre for Brain and Cognitive Development [Birkbeck College], Birkbeck College [University of London], Icahn School of Medicine at Mount Sinai [New York], University of Toronto, University of Cyprus [Nicosia], Janssen Research & Development, University of Messina, This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ inkind contributions, and from Autism Speaks., European Project : 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS ( 2012 ), Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of Cambridge [UK] (CAM), Department of Child and Adolescent Psychiatry and Psychotherapy [Mannheim], Universität Heidelberg [Heidelberg] = Heidelberg University, Stockholm County Council, Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Università Campus Bio-Medico di Roma / University Campus Bio-Medico of Rome ( UCBM), University of Reading (UOR), Universitätsklinikum Frankfurt, Roche Pharma Research and Early Development [Basel] (pRED), University of London [London], Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Cyprus [Nicosia] (UCY), Donders Institute for Brain, Cognition and Behaviour, Radboud University [Nijmegen], This work was supported by EU-AIMS (European Autism Interventions), which receives support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and from Autism Speaks., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Radboud university [Nijmegen], Lombardo, Michael V. [0000-0001-6780-8619], Charman, Tony [0000-0003-1993-6549], Loth, Eva [0000-0001-9458-9167], Tillmann, Julian [0000-0001-9574-9855], Crawley, Daisy [0000-0001-9901-1110], Ahmad, Jumana [0000-0001-5271-0731], Banaschewski, Tobias [0000-0003-4595-1144], Baron-Cohen, Simon [0000-0001-9217-2544], Brogna, Claudia [0000-0002-9526-6367], Dumas, Guillaume [0000-0002-2253-1844], Hayward, Hannah [0000-0001-5552-2146], Hipp, Joerg [0000-0002-7875-2988], Isaksson, Johan [0000-0003-1033-2618], Johnson, Mark [0000-0003-4229-2585], Jones, Emily JH [0000-0001-5747-9540], Lai, Meng-Chuan [0000-0002-9593-5508], Lythgoe, David J [0000-0002-5078-9025], Moessnang, Carolin [0000-0003-4357-2706], Ruggeri, Barbara [0000-0002-6231-8829], Ruigrok, Amber [0000-0001-7711-8056], Simonoff, Emily [0000-0002-5450-0823], Toro, Roberto [0000-0002-6671-858X], Williams, Steve CR [0000-0003-4299-1941], Murphy, Declan GM [0000-0002-6664-7451], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Parents
Male
[SDV]Life Sciences [q-bio]
Autism
[ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
Individuality
Behaviours
Severity of Illness Index
lcsh:RC346-429
psyc
0302 clinical medicine
Age
autism
autism spectrum disorder
behaviours
heterogeneity
IQ
phenotype
sex
molecular biology
developmental neuroscience
developmental biology
psychiatry and mental health
Surveys and Questionnaires
Longitudinal Studies
Autism spectrum disorder
Child
Psychiatry
Age
autism
autism spectrum disorder
behaviours
heterogeneity
IQ
phenotype
sex
molecular biology
developmental neuroscience
developmental biology
psychiatry and mental health
05 social sciences
Neuropsychology
Age Factors
220 Statistical Imaging Neuroscience
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Cognition
Psychiatry and Mental health
Phenotype
Cohort
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Female
Sex
Psychology
050104 developmental & child psychology
Adult
medicine.medical_specialty
Adolescent
BF
behavioral disciplines and activities
150 000 MR Techniques in Brain Function
Psykiatri
03 medical and health sciences
Genetic Heterogeneity
[ SHS.PSY ] Humanities and Social Sciences/Psychology
Sex Factors
Developmental Neuroscience
Severity of illness
mental disorders
medicine
Journal Article
Humans
0501 psychology and cognitive sciences
Molecular Biology
lcsh:Neurology. Diseases of the nervous system
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Research
medicine.disease
R1
Clinical trial
Impulsive Behavior
Observational study
Self Report
Heterogeneity
030217 neurology & neurosurgery
Biomarkers
Developmental Biology
Zdroj: Molecular Autism
Molecular Autism, BioMed Central, 2017, 8 (1), pp.27. 〈10.1186/s13229-017-0145-9〉
Charman, T, Loth, E, Tillmann, J, Crawley, D, Wooldridge, C, Goyard, D, Ahmad, J, Auyeung, B, Ambrosino, S, Banaschewski, T, Baron-Cohen, S, Baumeister, S, Beckmann, C, Bölte, S, Bourgeron, T, Bours, C, Brammer, M, Brandeis, D, Brogna, C, De Bruijn, Y, Chakrabarti, B, Cornelissen, I, Dell' Acqua, F, Dumas, G, Durston, S, Ecker, C, Faulkner, J, Frouin, V, Garcés, P, Ham, L, Hayward, H, Hipp, J, Holt, R J, Isaksson, J, Johnson, M H, Jones, E J H, Kundu, P, Lai, M C, D'ardhuy, X L, Lombardo, M V, Lythgoe, D J, Mandl, R, Mason, L, Meyer-Lindenberg, A, Moessnang, C, Mueller, N, O'Dwyer, L, Oldehinkel, M, Oranje, B, Pandina, G, Persico, A M, Ruggeri, B, Ruigrok, A N V, Sabet, J, Sacco, R, Cáceres, A S J, Simonoff, E, Toro, R, Tost, H, Waldman, J, Williams, S C R, Zwiers, M P, Spooren, W, Murphy, D G M & Buitelaar, J K 2017, ' The EU-AIMS Longitudinal European Autism Project (LEAP) : Clinical characterisation ', Molecular Autism, vol. 8, no. 1, 27 . https://doi.org/10.1186/s13229-017-0145-9
Molecular Autism [E], 8(1). BioMed Central
Molecular Autism, 8
Charman, T, Loth, E, Tillmann, J, Crawley, D, Wooldridge, C, Goyard, D, Ahmad, J, Auyeung, B, Ambrosino, S, Banaschewski, T, Baron-Cohen, S, Baumeister, S, Beckmann, C, Bölte, S, Bourgeron, T, Bours, C, Brammer, M, Brandeis, D, Brogna, C, Bruijn, Y D, Chakrabarti, B, Cornelissen, I, Dell’ Acqua, F, Dumas, G, Durston, S, Ecker, C, Faulkner, J, Frouin, V, Garces, P, Ham, L, Hayward, H, Hipp, J, Holt, R J, Isaksson, J, Johnson, M H, Jones, E J H, Kundu, P, Lai, M-C, Liogier D’ardhuy, X, Lombardo, M V, Lythgoe, D J, Mandl, R, Mason, L, Meyer-Lindenberg, A, Moessnang, C, Mueller, N, O’Dwyer, L, Oldehinkel, M, Oranje, B, Pandina, G, Persico, A M, Ruggeri, B, Ruigrok, A N V, Sabet, J, Sacco, R, San Jóse Cacéres, A, Simonoff, E, Toro, R, Tost, H, Waldman, J, Williams, S C R, Zwiers, M P, Spooren, W, Murphy, D G M & Buitelaar, J K 2017, ' The EU-AIMS Longitudinal European Autism Project (LEAP) : Clinical characterisation ', Molecular Autism, vol. 8, no. 27, pp. 1-21 . https://doi.org/10.1186/s13229-017-0145-9
Molecular Autism, 2017, 8, pp.27. ⟨10.1186/s13229-017-0145-9⟩
Molecular Autism, BioMed Central, 2017, 8, pp.27. ⟨10.1186/s13229-017-0145-9⟩
Molecular Autism, Vol 8, Iss 1, Pp 1-21 (2017)
ISSN: 2040-2392
DOI: 10.1186/s13229-017-0145-9〉
Popis: Background The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. Methods From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. Results The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. Conclusions The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. Electronic supplementary material The online version of this article (doi:10.1186/s13229-017-0145-9) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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