Supraglottic squamous cell carcinomas have distinctive clinical features and prognosis based on subregion

Autor: Shaoyun Cui, Weiquan Ding, Ankui Yang, Guorong Zou, Jiangang Liang, Tianrun Liu, Weiwei Cai, Tingbao Hu
Rok vydání: 2017
Předmět:
Male
Oncology
Pathology
Cancer Treatment
lcsh:Medicine
Kaplan-Meier Estimate
Pathology and Laboratory Medicine
Metastasis
0302 clinical medicine
Basic Cancer Research
Medicine and Health Sciences
lcsh:Science
030223 otorhinolaryngology
Human papillomavirus 16
Univariate analysis
Multidisciplinary
Human papillomavirus 18
Squamous Cell Carcinomas
Middle Aged
Prognosis
Surgical Oncology
Medical Microbiology
Lymphatic Metastasis
Viral Pathogens
030220 oncology & carcinogenesis
Viruses
Carcinoma
Squamous Cell
Female
Pathogens
Anatomy
Research Article
Clinical Oncology
Glottis
medicine.medical_specialty
Papillomaviruses
Surgical and Invasive Medical Procedures
Carcinomas
Microbiology
Lymphatic System
03 medical and health sciences
Diagnostic Medicine
Internal medicine
medicine
Carcinoma
Humans
Laryngeal Neoplasms
Microbial Pathogens
Survival rate
Survival analysis
Aged
Neoplasm Staging
Proportional Hazards Models
Biology and life sciences
Proportional hazards model
business.industry
lcsh:R
Organisms
Cancers and Neoplasms
Human Papillomavirus
medicine.disease
DNA
Viral
Supraglottic Squamous Cell Carcinoma
Supraglottic Carcinoma
lcsh:Q
Lymph Nodes
Neoplasm Grading
Clinical Medicine
DNA viruses
business
Follow-Up Studies
Zdroj: PLoS ONE, Vol 12, Iss 11, p e0188322 (2017)
PLoS ONE
ISSN: 1932-6203
Popis: Objective To analyze the clinicopathologic characteristics and prognosis of patients with squamous cell carcinoma localized to different supraglottic subregions. Methods Clinicopathologic data were reviewed retrospectively for 111 patients with supraglottic squamous cell carcinoma who were diagnosed between January 1, 1995 and December 31, 2005 and were initially treated with surgery. DNA from human papillomavirus (HPV) 16 and (or /and) HPV 18 were detected in all the 111 supraglottic carcinoma specimens using in situ hybridization. Survival analysis was performed by Kaplan-Meier analysis, factors were compared using log-rank test, and prognostic factors were determined using Cox proportional hazards model. The relationship between subregions and clinicopathologic factors was analyzed using Chi-square tests. Results HPV prevalence differed between patients with aryepiglottic fold carcinoma and ventricle carcinoma (P < .05). The local-regional control rates, overall survival rates or cancer specific survival rates were significantly different between different subregions. Univariate analysis indicated that pTNM classification, pN spread, and subregion were associated with prognosis (P < .05). Multivariate analysis indicated that pTNM classification and subregion were associated with supraglottic carcinoma prognosis. The survival rate was better for patients with carcinoma of the epiglottis or ventricular bands compared to those with carcinoma in the aryepiglottic fold or ventricle (P = .012). Conclusions Subregion may be a new prognostic factor for supraglottic squamous cell carcinoma. Different supraglottic carcinoma subregions have distinct clinical features such as HPV expression, lymph node metastasis rate, local-regional control and prognosis. Therefore, it is necessary to subdivide supraglottic squamous cell carcinomas into several subregion groups to individualize therapy.
Databáze: OpenAIRE
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