Improvement of 'Bouncy Gait' in Lance-Adams Syndrome with Perampanel
| Autor: | Ai Huey Tan, Dushyanth Babu Jasti, Shen-Yang Lim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Physical Medicine & Rehabilitation
negative myoclonus 030204 cardiovascular system & hematology 03 medical and health sciences Perampanel chemistry.chemical_compound Muscle tone 0302 clinical medicine perampanel Internal Medicine medicine Bouncy gait lance-adams syndrome Polypharmacy business.industry General Engineering myoclonus Clonazepam medicine.anatomical_structure Neurology chemistry Anesthesia bouncy gait Levetiracetam medicine.symptom Acetazolamide business Myoclonus 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.6773 |
| Popis: | Lance-Adams syndrome (LAS) is chronic post-hypoxic myoclonus that is often associated with sudden lapses in muscle tone (negative myoclonus) in the legs, causing a disabling "bouncy gait." Given its relative rarity, there are no controlled treatment studies of LAS. The majority of cases require polypharmacy management, with an incomplete response. "Bouncy gait," in particular, is notoriously medication-refractory. Here, we report a patient with long-standing LAS who improved markedly when low-dose perampanel was added to his existing treatment regime consisting of clonazepam, levetiracetam, sodium valproate, and acetazolamide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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