Metabolic effects of tibolone in postmenopausal women with non-insulin dependent diabetes mellitus
| Autor: | Gordana M. Prelevic, Jean Ginsburg, Teodora Beljic, Ljiljana Balint-Peric |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Time Factors Norpregnenes medicine.medical_treatment Blood lipids Tibolone General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Anabolic Agents Diabetes mellitus Internal medicine Humans Insulin Medicine Longitudinal Studies Prospective Studies Triglyceride business.industry Cholesterol Obstetrics and Gynecology Fasting Middle Aged Lipid Metabolism Postprandial Period medicine.disease Lipids Postmenopause Menopause Endocrinology Postprandial Diabetes Mellitus Type 2 chemistry Fructosamine Female lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | Maturitas. 28:271-276 |
| ISSN: | 0378-5122 |
| DOI: | 10.1016/s0378-5122(97)00074-1 |
| Popis: | Objective: Postmenopausal women with non-insulin dependent diabetes (NIDDM) are frequently obese, hypertensive and hyperlipidaemic and hence at particular risk of coronary heart disease (CHD). They might therefore benefit from menopausal therapy. In view of the improvement in insulin sensitivity and the reduction in triglyceride levels induced by tibolone in healthy postmenopausal women we evaluated the effects of 12 months of tibolone on glycaemic control, serum insulin and lipid levels in postmenopausal women with NIDDM. Design: A prospective 12 months before/after intervention study. Patients: Fourteen postmenopausal women (mean age 58.14±1.25 years; mean duration of menopause 121.21±13.42 months; mean BMI: 26.55±0.97) with NIDDM (mean duration of diabetes 113.79±13.89 months). Measurements: Fasting and postprandial blood glucose levels were assessed monthly, serum fructosamine, fasting and postprandial insulin every 3 months and serum lipids (total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol) every 6 months. Results: Changes in blood glucose, both fasting and postprandial, were not statistically significant during the treatment period. Serum fructosamine concentration increased significantly after 9 months. A significant decrease in fasting and postprandial insulin concentrations was observed after 9 months. A non-significant decrease was observed in total cholesterol, LDL cholesterol and triglyceride but no change in HDL cholesterol. Body weight did not change during the period of observation. Conclusion: A slight deterioration in glycaemic control, a fall in insulin concentration and no change in serum lipids were observed in women with NIDDM during 12 months treatment with tibolone. |
| Databáze: | OpenAIRE |
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