Regulation of α-Transducin and α-Gustducin Expression by a High Protein Diet in the Pig Gastrointestinal Tract
| Autor: | Paolo Clavenzani, Monica Forni, Cristiano Bombardi, Roberto De Giorgio, Rocco Latorre, Claudia Vallorani, Maria Laura Bacci, Mirella Falconi, Catia Sternini, Maurizio Mazzoni |
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| Přispěvatelé: | DE GIORGIO, Roberto, Mazzoni, Maurizio, Vallorani, Claudia, Latorre, Rocco, Bombardi, Cristiano, Bacci, MARIA LAURA, Forni, Monica, Falconi, Mirella, Catia, Sternini, Clavenzani, Paolo |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
pig Taste Swine chemosensing Sus scrofa lcsh:Medicine Social Sciences Enteroendocrine cell Biochemistry Signaling Molecules 0302 clinical medicine Cell Signaling Taste receptor Medicine and Health Sciences Psychology α-gustducin α-transducin taste receptors high-protein diet enteroendocrine cells lcsh:Science Mammals Gastrointestinal tract Multidisciplinary Neurochemistry Agriculture Neurotransmitters Ghrelin Jejunum 030220 oncology & carcinogenesis Vertebrates Female Sensory Perception Dietary Proteins Transducin Anatomy Research Article Signal Transduction medicine.medical_specialty Cell signaling Biogenic Amines Serotonin Livestock G protein Duodenum Biology NO 03 medical and health sciences Internal medicine medicine Animals Nutrition lcsh:R Organisms Correction Biology and Life Sciences Cell Biology Gustducin Diet Large Intestine Gastrointestinal Tract 030104 developmental biology Endocrinology lcsh:Q Digestive System 030217 neurology & neurosurgery α-gustducin α-transducin taste receptors high-protein diet enteroendocrine cells chemosensing pig Neuroscience |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 2, p e0148954 (2016) PLoS ONE, Vol 11, Iss 3, p e0152647 (2016) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND:The expression of taste receptors (TASRs) and their signalling molecules in the gastrointestinal (GI) epithelial cells, including enteroendocrine cells (EECs), suggests they participate in chemosensing mechanisms influencing GI physiology via the release of endocrine messengers. TASRs mediate gustatory signalling by interacting with different transducers, including α-gustducin (Gαgust) and α-transducin (Gαtran) G protein subunits. This study tested whether Gαtran and Gαgust immunoreactive (-IR) cells are affected by a short-term (3 days) and long-term (30 days) high protein (Hp) diet in the pig GI tract. RESULT:In the stomach, Gαgust and Gαtran-IR cells contained serotonin (5-HT) and ghrelin (GHR), while in the small and large intestine, Gαgust and Gαtran-IR colocalized with 5-HT-, cholecystokinin (CCK)- and peptide YY (PYY)-IR. There was a significant increase in the density of Gαtran-IR cells in the pyloric mucosa in both short- and long-term Hp diet groups (Hp3 and Hp30) vs. the control group (Ctr) (P |
| Databáze: | OpenAIRE |
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