Immunological and angiogenic markers during metronomic temozolomide and cyclophosphamide in canine cancer patients
| Autor: | Laetitia Cicchelero, Sofie Denies, Sylvie Daminet, Ingeborgh Polis, Niek N. Sanders, I. Van de Maele, H. de Rooster |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Vascular Endothelial Growth Factor A Cyclophosphamide Angiogenesis medicine.medical_treatment chemical and pharmacologic phenomena Pharmacology T-Lymphocytes Regulatory Thrombospondin 1 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dogs Neoplasms medicine Temozolomide Animals Dog Diseases Lymphocyte Count Antineoplastic Agents Alkylating Chemotherapy General Veterinary business.industry FOXP3 Cancer hemic and immune systems medicine.disease Metronomic Chemotherapy Vascular endothelial growth factor Dacarbazine 030104 developmental biology chemistry 030220 oncology & carcinogenesis Case-Control Studies Administration Metronomic Cancer research business medicine.drug |
| Zdroj: | Veterinary and comparative oncology. 15(2) |
| ISSN: | 1476-5829 |
| Popis: | Metronomic chemotherapy stimulates the immune response via depletion of regulatory T cells (Tregs) and suppresses angiogenesis by modulating the secretion of thrombospondin-1 (TSP-1) and vascular endothelial growth factor (VEGF). In this study, blood was collected from 10 healthy dogs and from 30 canine cancer patients before and 2 and 4 weeks after treatment with metronomic temozolomide (6.6 mg m−2), cyclophosphamide (12.5 mg m−2) or cyclophosphamide and temozolomide. The percentage of circulating CD25+Foxp3+CD4+ Tregs and the plasma levels of TSP-1 and VEGF were measured. There was a significant difference in the percentage of Tregs between cancer patients and healthy dogs. A significant decrease in Tregs was noted in patients treated with metronomic cyclophosphamide and the combination. Treatment with temozolomide had no effect on the percentage of Tregs. TSP-1 and VEGF levels were, respectively, significantly lower and higher in cancer patients than in healthy dogs, but they were not influenced by any of the studied metronomic treatment regimens. |
| Databáze: | OpenAIRE |
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