Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic diabetes insipidus

Autor:	Beril, Erdem Tuncdemir
Rok vydání:	2022
Předmět:	Cell Biology Molecular Biology Biochemistry
Zdroj:	Journal of Receptors and Signal Transduction. 42:573-579
ISSN:	1532-4281 1079-9893
Popis:	Loss-of-function mutations of the arginine vasopressin receptor 2 gene (AVPR2) cause Nephrogenic diabetes insipidus (NDI). AVPR2 is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP accumulation in the cell as a secondary messenger. Recent studies showed that some AVPR2 mutations could cause biased Gαq/11 protein coupling rather than Gαs. Investigation into the characterization of biased receptors may give insights into the relationship between the conformational change of the receptor because of the mutation and related downstream signaling. In this study, R68W and V162A were analyzed to whether they show a bias to Gαs or Gαq/11 proteins. Their functionality in terms of cAMP production
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c882f4c619aefe2a5c0aee6bc4e34e0e https://doi.org/10.1080/10799893.2022.2102651 Zobrazit plný text záznamu