Fatal hepatitis B reactivation treated with entecavir in an isolated anti-HBs positive lymphoma patient: A case report and literature review
| Autor: | Mário Júlio Campos, Joana Torres, Cláudia Agostinho, Alexandra Fernandes, Rosa Ferreira, Sofia Mendes, Sílvia Giestas, Joana Carvalheiro |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
HBsAg
reactivation Guanine medicine.medical_treatment Antineoplastic Agents Case Report lymphoma medicine.disease_cause Antiviral Agents Antibodies Monoclonal Murine-Derived Fatal Outcome medicine Humans Hepatitis B Antibodies lcsh:RC799-869 Aged Hepatitis B virus Chemotherapy business.industry Gastroenterology virus diseases Entecavir Hepatitis B Jaundice medicine.disease digestive system diseases Lymphoma Immunology Anti-HBs positive Female Virus Activation Rituximab lcsh:Diseases of the digestive system. Gastroenterology Lymphoma Large B-Cell Diffuse medicine.symptom business hepatitis B virus medicine.drug entecavir |
| Zdroj: | The Saudi Journal of Gastroenterology, Vol 18, Iss 4, Pp 277-281 (2012) Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association |
| ISSN: | 1998-4049 1319-3767 |
| Popis: | Hepatitis B virus (HBV) reactivation is a well-recognized complication that occurs in lymphoma patients who undergo chemotherapy. Only very few cases of HBV reactivation in patients with isolated antibody against hepatitis B surface antigen (anti-HBs) have been reported. We present a case of a 78-year-old woman diagnosed with diffuse large B cell non-Hodgkin's lymphoma who only displayed a positive anti-HBs, as the single possible marker of occult HBV infection, before starting therapy. She was treated with several chemotherapeutic regimens (including rituximab) for disease relapses during 3 years. Forty days after the last cycle of chemotherapy, she presented with jaundice, markedly elevated serum aminotransferase levels, and coagulopathy. HBV serology showed positivity for HBsAg, anti-HBc and anti-HBs. HBV DNA was positive. Antiviral treatment with entecavir was promptly initiated, but the patient died from liver failure. A review of the literature of HBV reactivation in patients with detectable anti-HBs levels is discussed. |
| Databáze: | OpenAIRE |
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