Month-to-month variability of lipids, lipoproteins, and apolipoproteins and the impact of acute infection in adolescents
| Autor: | Samuel S. Gidding, Lisa Bookstein, Peter M. Laskarzewski, Neil J. Stone, Evan A. Stein |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Apolipoprotein B Lipoproteins Apolipoproteins A Infections chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Humans Apolipoproteins B biology Cholesterol business.industry Cholesterol HDL Lipoprotein(a) Lipids Apolipoproteins Endocrinology chemistry Low-density lipoprotein Acute Disease Pediatrics Perinatology and Child Health biology.protein Female lipids (amino acids peptides and proteins) Apolipoprotein A1 business Lipoprotein |
| Zdroj: | The Journal of Pediatrics. 133:242-246 |
| ISSN: | 0022-3476 |
| Popis: | Objective: To assess month-to-month variability of total cholesterol, triglycerides, high-density lipoprotein–cholesterol (HDL-C), calculated low-density lipoprotein–cholesterol (LDL-C), apolipoprotein A1, apolipoprotein B, and lipoprotein (a), as well as factors that could influence variability, including recent acute infection in an adolescent population. Methods: Sixty-three high school students had fasting lipids and lipoproteins measured at 4 separate times during the school year and another venipuncture 3 to 7 days after recovery from an acute infection. Erythrocyte sedimentation rate was also measured. Coefficients of variation were calculated for each study variable. The influence of recent infection on variability was assessed. Results: The 50th and 95th percentiles, respectively, for the coefficient of variation for each variable were as follows: total cholesterol, 7.3% and 13.6%; triglycerides, 22% and 47.3%; HDL-C, 7.9% and 16.8%; LDL-C, 12.1% and 25%; apolipoprotein A1, 6.3% and 15.2%; apolipoprotein B, 9.5% and 17.2%; and lipoprotein (a), 19.3% and 40%. Recent infection significantly lowered HDL-C (4 mg/dL; P < .0001) and apolipoprotein A1 (7 mg/dL; P < .005). Conclusions: Clinicians evaluating lipids and lipoproteins serially should expect significant visit-to-visit variation in triglycerides and calculated LDL-C values. Assessment of HDL-C and apolipoprotein A1 should not be done within 2 weeks of an acute infection. Apolipoproteins B and A1 have slightly less variability than their respective lipoprotein cholesterol values (LDL-C and HDL-C). (J Pediatr 1998;133:242-6) |
| Databáze: | OpenAIRE |
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