Metabolism of the mercapturic acid of 2,4',5-trichlorobiphenyl in rats and mice
| Autor: | Ingvar Brandt, Per Ola Darnerud, C. B. Struble, Jerome E. Bakke, A. L. Bergman |
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| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.medical_specialty Health Toxicology and Mutagenesis Bronchi Toxicology Biochemistry Feces Mice Oral administration Internal medicine medicine Animals Tissue Distribution Mercapturic acid Respiratory system Lung Pharmacology chemistry.chemical_classification Mucous Membrane Chemistry Rats Inbred Strains General Medicine Metabolism Polychlorinated Biphenyls Acetylcysteine Rats Mice Inbred C57BL Endocrinology medicine.anatomical_structure Thiol Autoradiography Female Hepatic portal vein |
| Zdroj: | Xenobiotica; the fate of foreign compounds in biological systems. 13(10) |
| ISSN: | 0049-8254 |
| Popis: | 1. 2,4′,5-Trichloro[14C]biphenyl mercapturic acids (triCB-MA) were metabolized in part to methylsulphide, methylsulphoxide and methylsulphone metabolites after i.p., i.v. (hepatic portal vein) and p.o. administration to rats.2 Methylthio-triCB and triCB-MA were present in faeces and 3- and 4-methylsulphonyl-triCB (triCB-SO2CH3) were present in carcasses of all rats. Only triCB-SO2CH3 was present in lung tissue.3. As shown by autoradiography, radioactivity accumulated in the tracheo-bronchial mucosa of mice given either intracaecal or tail-vein injections of triCB-MA.4. Radioactivity extracted from the lungs of mice was shown to be present as triCB-SO2CH3. |
| Databáze: | OpenAIRE |
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