Selenium Biofortification: Roles, Mechanisms, Responses and Prospects
| Autor: | Pardeep Kumar, Sukamal Sarkar, Sagar Maitra, Mousumi Mondal, Milan Skalicky, Alison M. Laing, Akbar Hossain, Pradipta Banerjee, Tofazzal Islam, Marian Brestic, Hindu Vemuri, Saikat Saha, Rajan Bhatt, Zahoor Ahmad, Sourav Garai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Microorganism Biofortification Pharmaceutical Science chemistry.chemical_element Review Biology Selenic Acid 01 natural sciences Antioxidants Analytical Chemistry lcsh:QD241-441 biofortification 03 medical and health sciences chemistry.chemical_compound Selenium Soil lcsh:Organic chemistry Drug Discovery Humans Physical and Theoretical Chemistry Selenomethionine Selenoproteins 030304 developmental biology Molecular breeding chemistry.chemical_classification 0303 health sciences Methionine Selenocysteine plants Organic Chemistry trace element Amino acid animals Human nutrition nutrition Biochemistry chemistry Chemistry (miscellaneous) Molecular Medicine 010606 plant biology & botany |
| Zdroj: | Molecules Molecules, Vol 26, Iss 881, p 881 (2021) |
| ISSN: | 1420-3049 |
| Popis: | The trace element selenium (Se) is a crucial element for many living organisms, including soil microorganisms, plants and animals, including humans. Generally, in Nature Se is taken up in the living cells of microorganisms, plants, animals and humans in several inorganic forms such as selenate, selenite, elemental Se and selenide. These forms are converted to organic forms by biological process, mostly as the two selenoamino acids selenocysteine (SeCys) and selenomethionine (SeMet). The biological systems of plants, animals and humans can fix these amino acids into Se-containing proteins by a modest replacement of methionine with SeMet. While the form SeCys is usually present in the active site of enzymes, which is essential for catalytic activity. Within human cells, organic forms of Se are significant for the accurate functioning of the immune and reproductive systems, the thyroid and the brain, and to enzyme activity within cells. Humans ingest Se through plant and animal foods rich in the element. The concentration of Se in foodstuffs depends on the presence of available forms of Se in soils and its uptake and accumulation by plants and herbivorous animals. Therefore, improving the availability of Se to plants is, therefore, a potential pathway to overcoming human Se deficiencies. Among these prospective pathways, the Se-biofortification of plants has already been established as a pioneering approach for producing Se-enriched agricultural products. To achieve this desirable aim of Se-biofortification, molecular breeding and genetic engineering in combination with novel agronomic and edaphic management approaches should be combined. This current review summarizes the roles, responses, prospects and mechanisms of Se in human nutrition. It also elaborates how biofortification is a plausible approach to resolving Se-deficiency in humans and other animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |