Bone pain from spinal metastases: Iodine-125 brachytherapy
| Autor: | Wenhui Zhang, Shiyan Lin, Hongxue Shao, Lei Teng, Liuyuan Zhao, Junzhu Dai, Huichao Zou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Oncology (nursing) business.industry medicine.medical_treatment Brachytherapy Analgesic Medicine (miscellaneous) General Medicine Iodine 125 brachytherapy Surgery Radiation therapy Medical–Surgical Nursing Quality of life Cohort medicine Morphine medicine.symptom Bone pain business medicine.drug |
| Zdroj: | BMJ supportivepalliative care. |
| ISSN: | 2045-4368 |
| Popis: | ObjectivesThis study evaluated the analgesic efficacy and safety of CT-guided iodine-125 (125I) brachytherapy in patients with spinal metastasis-induced pain who were not suitable to receive radiotherapy.MethodsA cohort of 68 patients with spinal metastasis induced pain not fully relieved by opioids and did not receive external beam radiation therapy due to poor general status were enrolled and underwent CT-guided 125I brachytherapy for analgesic treatment.ResultsPatients were followed for 8 weeks after brachytherapy. Mean Numerical Rating Scale score before brachytherapy was 7.3±1.3 and decreased to 3.3±0.9, 2.6±0.8, 2.7±0.8, 2.9±0.9 and 3.3±1.1 at weeks 1, 2, 4, 6 and 8, respectively, after brachytherapy. Daily dose of morphine equivalent was 105.1±28.0 mg before brachytherapy and decreased to 45.3±13.7, 39.9±14.2, 40.4±14.9, 48.5±18.0 and 62.4±17.5 mg at weeks 1, 2, 4, 6 and 8, respectively, after brachytherapy. Patients had fewer daily episodes of breakthrough pain after brachytherapy (pConclusionsCT-guided 125I brachytherapy is an effective and safe intervention for patients with spinal metastasis-induced pain who are not able to receive radiation therapy. |
| Databáze: | OpenAIRE |
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