Actin cytoskeleton organization in response to integrin-mediated adhesion
| Autor: | Laura Dolce, Guido Tarone, Cristina Olivo, Paola Defilippi, Lorenzo Silengo, Mascia Venturino |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Integrins
animal structures Histology Stress fiber Phalloidine macromolecular substances Protein Serine-Threonine Kinases Actin cytoskeleton organization GTP Phosphohydrolases Focal adhesion Mice Cell-matrix adhesion Cell Adhesion Animals Pseudopodia cdc42 GTP-Binding Protein Instrumentation Cytoskeleton Protein Kinase C Chemistry 3T3 Cells Actin cytoskeleton Immunohistochemistry Actins Extracellular Matrix Fibronectins Cell biology Enzyme Activation Medical Laboratory Technology Microscopy Fluorescence MDia1 Anatomy Lamellipodium Proto-Oncogene Proteins c-akt Filopodia |
| Zdroj: | Microscopy Research and Technique. 47:67-78 |
| ISSN: | 1097-0029 1059-910X |
| DOI: | 10.1002/(sici)1097-0029(19991001)47:1<67::aid-jemt7>3.0.co;2-p |
| Popis: | Cell matrix adhesion regulates actin cytoskeleton organization through distinct steps, from formation of filopodia and lamellipodia in the early phases of cell adhesion to organization of focal adhesions and stress fibers in fully adherent cells. In this review, we follow the events induced by integrin-mediated adhesion, such as activation of GTPases Cdc42 and Rac and their effectors and their role in actin polymerization leading to formation of lamellipodia and filopodia and cell spreading. We also show that actin stress fiber and focal adhesion formation following adhesion requires cooperation between integrin-mediated signaling and additional stimuli, including activation of PKC, Rho GTPases, and PTKs such as p125Fak and Src. |
| Databáze: | OpenAIRE |
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