E-cadherin expression in lymph nodes of three patients with non-Hodgkin's lymphoma
| Autor: | Kensuke Ohta, Tomio Kamitani, Takayuki Takubo, Kaori Makita, Masayuki Hino, Yasutaka Aoyama, Yoshiki Terada, Takahisa Yamane, Noriyuki Tatsumi, Ryousuke Yamamura, K Ohshima, Hiroshi Kanashima, K Tanaka, Etsuko Shima, Hirohisa Nakamae, H Shibata |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Enzyme-Linked Immunosorbent Assay Antigen immune system diseases hemic and lymphatic diseases Medicine Humans Cell adhesion Aged Aged 80 and over business.industry Cell adhesion molecule Cadherin Lymphoma Non-Hodgkin Hematology Middle Aged medicine.disease Cadherins Immunohistochemistry Lymphoma Non-Hodgkin's lymphoma Neoplasm Proteins Case-Control Studies Female Lymph Lymph Nodes business |
| Zdroj: | Haematologia. 32(1) |
| ISSN: | 0017-6559 |
| Popis: | The E-cadherins are a family of cell-cell adhesion molecules. These molecules exhibit Ca2+ dependent cell adhesion and are expressed on epithelial cells. E-cadherin levels in serum are known to be significantly elevated in patients with epithelial carcinomas. We determined serum E-cadherin levels in 30 patients with non-Hodgkin's lymphoma (NHL) using an enzyme immunoassay and then investigated whether E-cadherin is expressed on lymphoma cells in lymph nodes of three cases selected to analyze from 15 cases of serum E-cadherin levels over mean + 2SD with monoclonal antibody immunohistochemistry. Results indicated that E-cadherin antigen is expressed on the lymphoma cells in these three patients with NHL, and that soluble E-cadherin might be released into blood from lymphoma cells. Expression of E-cadherin may contribute to the morphological appearance of some malignant lymphoma, although no conclusion can be drawn based on such small number of patients analyzed. |
| Databáze: | OpenAIRE |
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