Prognosis in patients with anaplastic oligoastrocytoma is associated with histologic grade
| Autor: | Caterina Giannini, Judith R. O'Fallon, Robert P. Dinapoli, Paula J. Schomberg, Paul L. Schaefer, Gist Farr, Bernd W. Scheithauer, Jan C. Buckner, Karla V. Ballman |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Neurology Adolescent medicine.medical_treatment Kaplan-Meier Estimate Astrocytoma Internal medicine medicine Humans In patient Anaplastic Oligoastrocytoma Aged Aged 80 and over Chemotherapy Clinical Trials as Topic business.industry Brain Neoplasms Histology Middle Aged medicine.disease Prognosis Radiation therapy Female Neurology (clinical) business Anaplastic astrocytoma |
| Zdroj: | Journal of neuro-oncology. 84(3) |
| ISSN: | 0167-594X |
| Popis: | Anaplastic oligoastrocytomas (AOA) are relatively uncommon high-grade gliomas. While oligodendroglial elements are thought to be associated with better outcomes, the magnitude of the difference is not clear. Between 1980 and 1999, Mayo Clinic and the NCCTG conducted 10 trials of radiation therapy and chemotherapy in adults with newly-diagnosed high-grade gliomas. All pathology slides were reviewed by one of the authors (BWS or CG). We grouped patients by cell type and grade, compared survival distributions by the log-rank statistic, and performed multiple variable analyses. Of 1368 patients, 68 (5%) had AOA, including 21 Grade 3 (OA3) and 47 grade 4 (OA4), 153 (11%) had anaplastic astrocytoma (AA), and 1147 (84%) had glioblastoma multiforme (GBM). Patients with OA3 survived significantly longer than those with OA4 (P = 0.0001) or AA (P = 0.0044). Patients with OA4 lived significantly longer than those with GBM (P = 0.0005). The same differences were noted for PFS. Prognostic factors for survival identified by multiple variable analysis were histology, age, ECOG performance score, and extent of surgical resection, but not treatment administered. Patients with anaplastic oligoastrocytoma have distinct outcomes based upon grade (OA3 vs. OA4) and in comparison with pure astrocytoma (AA or GBM). Future trials which include more than one histologic entity need to report results by cell type and grade and account for the varying prognoses in interpreting treatment outcomes. |
| Databáze: | OpenAIRE |
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