Histological and Immunohistochemical Analyses of Repair of the Disc in the Rabbit Temporomandibular Joint Using a Collagen Template
| Autor: | Charn Bing Yang, Wen Fu Lai, Wing P. Chan, Yu Hui Tsai, Hung Li Tsai, Li Hsuan Chiu, Kuan Chou Chen, Chia Lang Fang, Kuo Hwa Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Materials science tissue regeneration Matrix (biology) lcsh:Technology Article Condyle Extracellular matrix 03 medical and health sciences 0302 clinical medicine temporomandibular joint disc medicine General Materials Science lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 reconstituted collagen template lcsh:T Regeneration (biology) Temporomandibular Joint Disc 030206 dentistry Temporomandibular joint Collagen type I alpha 1 medicine.anatomical_structure lcsh:TA1-2040 030220 oncology & carcinogenesis lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 Type I collagen |
| Zdroj: | Materials, Vol 10, Iss 8, p 924 (2017) Materials Materials; Volume 10; Issue 8; Pages: 924 |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma10080924 |
| Popis: | A previous study demonstrated that the reconstituted type I collagen matrix extracted from rabbit tendons enabled the TMJ disc to regenerate in the rabbit. The aim of this study was to investigate changes in the extracellular matrix (ECM) and mechanisms of regeneration in the TMJ disc. In 36 New Zealand rabbits that underwent a partial discectomy, discs were replaced with reconstituted collagen templates for 3 months. A histological analysis showed that moderate to severe degeneration appeared in partially discectomized joints without implantation. In contrast, discs experienced regeneration of reconstituted collagen template implantation and the joint returned to normal function. Cells in the regenerative tissue expressed ECM, and fibers became regular and compact due to tissue remodeling over time. Reparative cells differentiated into chondroblasts, and showed highly dense pericellular fibers. The morphology and collagen composition of the disc and condyle in the 3-month experimental group were similar to those of normal tissues. In conclusion, the reconstituted collagen template facilitated the regeneration of surgically discectomized discs. Type I and type II collagens play a crucial role in the regeneration of articular discs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|