Functional adaptation of bovine mesenteric lymphatic vessels to mesenteric venous hypertension
| Autor: | Anatoliy A. Gashev, Randolph H. Stewart, John C. Criscione, Glen A. Laine, Joanne Hardy, Emily Wilson, Ranjeet M. Dongaonkar, Christopher M. Quick, Akhilesh A. Kotiya |
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| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Time Factors Fluid and Electrolyte Homeostasis Physiology Mesenteric Vein Microcirculation Lymphatic System Mesenteric Veins Interstitial fluid Physiology (medical) Internal medicine medicine Animals Mesentery Lymphatic Vessels business.industry Sham surgery Anatomy Water-Electrolyte Balance Adaptation Physiological Disease Models Animal medicine.anatomical_structure Lymphatic system Hypertension Cardiology Cattle Female Lymph business Lymphangion |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 306:R901-R907 |
| ISSN: | 1522-1490 0363-6119 |
| Popis: | Lymph flow is the primary mechanism for returning interstitial fluid to the blood circulation. Currently, the adaptive response of lymphatic vessels to mesenteric venous hypertension is not known. This study sought to determine the functional responses of postnodal mesenteric lymphatic vessels. We surgically occluded bovine mesenteric veins to create mesenteric venous hypertension to elevate mesenteric lymph flow. Three days after surgery, postnodal mesenteric lymphatic vessels from mesenteric venous hypertension (MVH; n = 7) and sham surgery (Sham; n = 6) group animals were evaluated and compared. Contraction frequency (MVH: 2.98 ± 0.75 min−1; Sham: 5.42 ± 0.81 min−1) and fractional pump flow (MVH: 1.14 ± 0.30 min−1; Sham: 2.39 ± 0.32 min−1) were significantly lower in the venous occlusion group. These results indicate that postnodal mesenteric lymphatic vessels adapt to mesenteric venous hypertension by reducing intrinsic contractile activity. |
| Databáze: | OpenAIRE |
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