Brain glucose utilization in systemic lupus erythematosus with neuropsychiatric symptoms: A controlled positron emission tomography study
| Autor: | E. U. Nitzsche, J Gutfleisch, Stefan Hoegerle, Freimut D. Juengling, Andreas Otte, Ernst Moser, M Goetze, Stefan M. Weiner, Hans-Hartmut Peter, Jan Mueller-Brand |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Systemic disease Pathology medicine.medical_specialty Fluorine Radioisotopes Deoxyglucose Central nervous system disease Fluorodeoxyglucose F18 medicine Brain positron emission tomography Humans Lupus Erythematosus Systemic Radiology Nuclear Medicine and imaging Fluorodeoxyglucose Brain Diseases Lupus erythematosus medicine.diagnostic_test business.industry Brain Magnetic resonance imaging General Medicine medicine.disease Connective tissue disease Magnetic Resonance Imaging Glucose Positron emission tomography Case-Control Studies Female Radiopharmaceuticals business medicine.drug Tomography Emission-Computed |
| Popis: | In contrast to morphological imaging [such as magnetic resonance imaging (MRI) or computed tomography], functional imaging may be of advantage in the detection of brain abnormalities in cases of neuropsychiatric systemic lupus erythematosus (SLE). Therefore, we studied 13 patients (aged 40+/-14 years, 11 female, 2 male) with neuropsychiatric SLE who met four of the American Rheumatism Association criteria for the classification of SLE. Ten clinically and neurologically healthy volunteers served as controls (aged 40+/-12 years, 5 female, 5 male). Both groups were investigated using fluorine-18-labelled fluorodeoxyglucose brain positron emission tomography (PET) and cranial MRI. The normal controls and 11 of the 13 patients showed normal MRI scans. However, PET scan was abnormal in all 13 SLE patients. Significant group-to-group differences in the glucose metabolic index (GMI=region of interest uptake/global uptake at the level of the basal ganglia and thalamus) were found in the parieto-occipital region on both sides: the GMI of the parieto-occipital region on the right side was 0.922+/-0.045 in patients and 1.066+/-0.081 in controls (P< |
| Databáze: | OpenAIRE |
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