The B-cell response to a primary and booster course of MenACWY-CRM197 vaccine administered at 2, 4 and 12 months of age
| Autor: | Dominic F. Kelly, Elizabeth A. Clutterbuck, Daniel H. O'Connor, Brigitte Ohene-Kena, Tatjana Odrljin, Tessa M. John, Chaam L. Klinger, Andrew J. Pollard, Matthew D. Snape, Geraldine Blanchard-Rohner |
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| Rok vydání: | 2013 |
| Předmět: |
Pediatrics
medicine.medical_specialty General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Booster immunisation Meningococcal vaccine Young infants MenACWY-CRM vaccine Vaccination Infectious Diseases medicine.anatomical_structure Antigen Immunology biology.protein Molecular Medicine Medicine sense organs Antibody business B cell |
| Zdroj: | Vaccine. 31:2441-2448 |
| ISSN: | 0264-410X |
| Popis: | A quadrivalent meningococcal vaccine conjugated to CRM197 (MenACWY-CRM197) is immunogenic in young infants. We assessed the memory B-cell and antibody responses after a primary and booster course of MenACWY-CRM197 in children. At 5 months of age, following primary immunisation, serogroup-specific memory B-cells were detectable in fewer than 25% of children, although protective antibody titres (hSBA≥4) were detectable in 69% of children against serogroup A and more than 95% against the other serogroups. At 12 months, before booster immunisation the percentages with hSBA≥4 were 5% for serogroup A, and between 44 and 70% for the other serogroups. One month after booster immunisation with MenACWY-CRM197 over 50% of children had detectable memory B-cells, and 91% had hSBA≥4 against serogroup A and more than 99% against the other serogroups. These data show that few antigen-specific anticapsular memory B-cells can be detected after two-doses priming with MenACWY-CRM197. For MenC and CRM197, the antigens with the highest number of B-cells at 5 months, there was a definite (p≤0.02) but weak correlation with antibody persistence at 12 months. Although previous studies suggest that measuring memory B-cell responses after priming immunisations in infancy can be used to predict antibody persistence and memory responses, this may not be suitable for all antigens in young children. © 2013 Elsevier Ltd. |
| Databáze: | OpenAIRE |
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