Possible Involvement of Histamine in Muscular Fatigue in Temporomandibular Disorders: Animal and Human Studies
| Autor: | J.-I. Huh, Tetsuji Inai, Akito Tsuboi, T. Tabata, Makoto Watanabe, Keiichi Sasaki, Y. Endo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male 0301 basic medicine Chlorpheniramine medicine.medical_specialty medicine.medical_treatment Analgesic Stimulation Histidine Decarboxylase Statistics Nonparametric Masseter muscle Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Facial Pain Internal medicine medicine Animals Humans Single-Blind Method General Dentistry Analysis of Variance Mice Inbred BALB C Muscle fatigue Masseter Muscle business.industry Anti-Inflammatory Agents Non-Steroidal 030206 dentistry Temporomandibular Joint Dysfunction Syndrome Histamine H1 Antagonists Electric Stimulation 030104 developmental biology Endocrinology Flurbiprofen chemistry Muscle Fatigue Antihistamine business Injections Intraperitoneal Histamine Interleukin-1 |
| Zdroj: | Journal of Dental Research. 78:769-775 |
| ISSN: | 1544-0591 0022-0345 |
| DOI: | 10.1177/00220345990780030901 |
| Popis: | As an approach to clarifying the molecular basis of pain and fatigue in muscles involved in temporomandibular disorders, we examined the activity of histidine decarboxylase (HDC), the enzyme which forms histamine, in the masseter muscles of mice. In the resting muscle, HDC activity was very low. Direct electrical stimulation of the muscle markedly elevated HDC activity. HDC activity rose within 3 hrs of the electrical stimulation, peaked at 6 to 8 hrs, and then gradually declined. Intraperitoneal injection of a small amount of interleukin-1 (IL-1) (from 1 to 10 μg/kg) produced a similar elevation of HDC activity in the masseter muscle. We also examined the effect of an antihistamine, chlorphenylamine (CP), on temporomandibular disorders in humans and compared it with that of an antiinflammatory analgesic, flurbiprofen (FB). Two groups received one or the other of the drugs daily for 7 days, and they were asked about their signs and symptoms before and after the treatment. A positive evaluation of their treatment was made by 74% of the CP group, but by only 48% of the FB group. Although the effects of CP on the limitation of mouth-opening and on joint noise were negligible, about 50% of the CP group answered positively concerning the drug's effect on spontaneous pain or pain induced by chewing or mouth-opening. The positive evaluation for CP (50%) in relieving associated symptoms (headache or shoulder stiffness) was significantly greater than for FB (13%). FB showed effectiveness similar to but sometimes weaker than that of CP on several symptoms. On the basis of these and previous results and the known actions of histamine, we propose that the histamine newly formed following the induction of HDC activity, which is itself mediated by IL-1, may be involved in inducing pain and, possibly, stiffness in muscles in temporomandibular disorders. |
| Databáze: | OpenAIRE |
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