| Autor: |
Gabriele Schönian, Harry P. de Koning, Saskia Decuypere, Keshav Rai, Mandy Sanders, Shyam Sundar, Basudha Khanal, Jean-Claude Dujardin, Bart Cuypers, Géraldine De Muylder, An Mannaert, Smriti Sharma, Benoit Vanhollebeke, Bart Ostyn, Hideo Imamura, Ilse Maes, Maya Berg, Frederik Van den Broeck, Marleen Boelaert, Manu Vanaerschot, Narayan Raj Bhattarai, Syamal Roy, Vijay Kumar Prajapati, Suman Rijal, Olivia Stark, Malgorzata A. Domagalska, Surendra Uranw, James Cotton, Luca Settimo, Franck Dumetz, Matthew Berriman, Tim Downing, Louis Maes |
| Přispěvatelé: |
Clinical sciences, Medical Genetics, Faculty of Sciences and Bioengineering Sciences, Biology, Faculty of Law and Criminology |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
eLife
eLife, Vol 5 (2016)
eLife, 5 (MARCH2016 |
| ISSN: |
2050-084X |
| Popis: |
Leishmania donovani causes visceral leishmaniasis (VL), the second most deadly vector- borne parasitic disease. A recent epidemic in the Indian subcontinent (ISC) caused up to 80% of global VL and over 30,000 deaths per year. Resistance against antimonial drugs has probably been a contributing factor in the persistence of this epidemic. Here we use whole genome sequences from 204 clinical isolates to track the evolution and epidemiology of L. donovani from the ISC. We identify independent radiations that have emerged since a bottleneck coincident with 1960s DDT spraying campaigns. A genetically distinct population frequently resistant to antimonials has a two base-pair insertion in the aquaglyceroporin gene LdAQP1 that prevents the transport of trivalent antimonials. We find evidence of genetic exchange between ISC populations, and show that the mutation in LdAQP1 has spread by recombination. Our results reveal the complexity of L. donovani evolution in the ISC in response to drug treatment.
SCOPUS: ar.j
info:eu-repo/semantics/published |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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