New classes of antibacterial oxazolidinones with C-5, methylene O-Linked heterocyclic side chains

Autor:	Michael B. Gravestock, Alexandra McGregor, Michael Dennis, R. Geoffrey Wilson, Lisa Woods, Alan Wookey, Michael John Betts, Glenn Hatter, Swain Michael Lingard, David G. Acton
Rok vydání:	2003
Předmět:	Staphylococcus aureus Stereochemistry Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Gram-Positive Bacteria Biochemistry Chemical synthesis Mice Structure-Activity Relationship chemistry.chemical_compound Heterocyclic Compounds Drug Discovery Side chain Animals Structure–activity relationship Methylene Molecular Biology Selection (genetic algorithm) Oxazolidinones Antibacterial agent Organic Chemistry General Medicine Staphylococcal Infections Combinatorial chemistry Hydrocarbons Anti-Bacterial Agents Rats chemistry Molecular Medicine Methane
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:4179-4186
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2003.07.033
Popis:	Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c874c281dd90c9f417e49a14b91e7749 https://doi.org/10.1016/j.bmcl.2003.07.033 Zobrazit plný text záznamu Full Text from ScienceDirect