Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives
| Autor: | Kayena D. Zaqueo, Juliana C. Sobrinho, Rodrigo G. Stábeli, Anderson M. Kayano, Leandro S. Moreira-Dill, Andreimar M. Soares, Rodrigo Simões-Silva, Rudson J. Holanda, Fernando P. Grabner, Ana Gómez, Saulo L. da Silva, José R. Almeida, Jorge Alfonso, Juliana P. Zuliani |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Biotechnological applications Computer science Snake venoms Pharmaceutical Science Proteins Snakes Computational biology complex mixtures Protein purification New therapeutics 03 medical and health sciences 030104 developmental biology Snake venom Venomics Drug Discovery Molecular targets Experimental biology Toxins Animals Humans Identification (biology) Biotechnology Snake Venoms |
| Zdroj: | Repositorio Universidad Regional Amazónica Universidad Regional Amazónica instacron:IKIAM |
| ISSN: | 1873-4316 |
| Popis: | Background Research involving snake venom has gradually surpassed the simple discovery of new molecules using purification and structural characterization processes, and extended to the identification of their molecular targets and the evaluation of their therapeutic potential. Nevertheless, this only became possible due to constant progress in experimental biology and protein purification approaches. Objective This review aims to discuss the main components of snake venoms that have been investigated for biotechnological purposes, and to discover how these promising biomolecules were obtained with the satisfactory degree of purity that have enabled such studies. Advances in purification technologies of various snake venom molecules have allowed for important discoveries of proteins and peptides with different biomedical and biotechnological applications. Result and conclusion It is believed that significant experimental and computational advances will arise in similar proportions in the coming years that will allow researchers to map the molecular regions responsible for their pharmacological actions, their respective mechanisms of action and their cell targets. |
| Databáze: | OpenAIRE |
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