The role of androgen receptors in vascular and cell proliferation of the prostate adenocarcinomas
| Autor: | Tomescu P, Andrei Pănuş, Petru Octavian Drăgoescu, Claudiu Mărgăritescu, Mihai Lucian Ştefănescu, Alex Emilian Stepan |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Embryology prostate adenocarcinoma Proliferation index Adenocarcinoma Pathology and Forensic Medicine Antigen Prostate androgen receptor Biomarkers Tumor Medicine Humans Cell Proliferation Original Paper Cluster of differentiation Cell growth business.industry Prostatic Neoplasms Cell Biology General Medicine Endoglin Prognosis Androgen receptor CD105 medicine.anatomical_structure Tumor progression Receptors Androgen Cancer research business Ki67 Developmental Biology |
| Zdroj: | Romanian Journal of Morphology and Embryology |
| ISSN: | 2066-8279 |
| Popis: | Prostate adenocarcinoma (PA) is by incidence and prognosis a unique model for investigating the biomolecular mechanisms involved in tumor progression. In this study, we analyzed the immunoexpression of androgen receptor (AR), cluster of differentiation 105 (CD105) and Ki67 for 61 cases of PA, in relation to the main clinicopathological parameters of the lesions. The AR scores, CD105 microvessel density (MVD) and Ki67 proliferation index (PI) were significantly higher in patients with serum prostate-specific antigen (PSA) above 20 ng∕mL, in ductal, colloid and sarcomatoid types of PA, in growth patterns 4-5 or mixed, respectively in the case of high-grade advanced stage tumors, with perineural and vascular invasion, as well as in groups with a reserved prognosis. The results obtained, reflected in the positive linear correlation of AR, CD105 and Ki67 expression, indicate synchronous endocrine, angiogenic and proliferative mechanisms involved in tumor progression, which can be used to optimize the targeted tumor therapy. |
| Databáze: | OpenAIRE |
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