Impact of hypofractionation and tangential beam IMRT on the acute skin reaction in adjuvant breast cancer radiotherapy

Autor: Alaa Ahmad Nour, Aziz Alaradi, Salam Abou Ghaida, Volker Rudat
Jazyk: angličtina
Předmět:
Adult
medicine.medical_treatment
Breast Neoplasms
Dose hypofractionation
Skin Diseases
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Breast cancer
medicine
Breast-conserving surgery
Humans
Neoplasm Invasiveness
Radiology
Nuclear Medicine and imaging
Prospective Studies
Radiation injuries
IMRT
Univariate analysis
Radiotherapy
business.industry
Radiotherapy Planning
Computer-Assisted
Research
Carcinoma
Ductal
Breast
Radiotherapy Dosage
Middle Aged
Prognosis
medicine.disease
Radiation therapy
Carcinoma
Lobular
Regimen
Carcinoma
Intraductal
Noninfiltrating
Dose Hypofractionation
Risk factors
Oncology
Radiology Nuclear Medicine and imaging
030220 oncology & carcinogenesis
Acute Disease
Female
Radiation Dose Hypofractionation
Radiotherapy
Adjuvant
Radiotherapy
Intensity-Modulated
business
Nuclear medicine
Body mass index
Mastectomy
Follow-Up Studies
Zdroj: Radiation Oncology (London, England)
ISSN: 1748-717X
DOI: 10.1186/s13014-016-0674-y
Popis: Background The purpose of the study was to evaluate the impact of multiple prognostic factors on the acute skin reaction in adjuvant breast cancer radiotherapy, in particular the impact of hypofractionation (HF) compared to conventional fractionation (CF) and tangential beam (TB) IMRT compared to three-dimensional conformal radiotherapy (3DCRT). Methods Two-hundred and sixty-six breast cancer patients with postoperative radiotherapy after breast conserving surgery or mastectomy were retrospectively evaluated. Patients were treated with HF (15 fractions of 2.67 Gy; n = 121) or CF (28 fractions of 1.8 Gy or 25 fractions of 2.0 Gy; n = 145) and TB-IMRT (n = 151) or 3DCRT (n = 115). The acute skin reactions were prospectively assessed using the CTCAE v4 grading scale. Ordinal regression analysis was used to assess the impact of possible prognostic factors on the maximal acute skin reaction. Results Grade 2 skin reactions were observed in 19 % of the patients treated with CF compared to 2 % treated with HF. On univariate analysis, the fractionation regimen, the PTV (breast versus chest wall), the volume of the PTV and the body mass index were significant prognostic factors for the maximum acute skin reaction. On multivariate analysis, the fractionation regimen (p
Databáze: OpenAIRE
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