Evaluation of the relationship between VRK2 , rs4380187 polymorphisms, and genetic susceptibility to schizophrenia in the Chinese Han population
| Autor: | Dafei Zhan, Hong Zhu, Zejuan Fu, Xianglai Liu, Zhan Lin, Qiankun Yao, Hailing Xie, Tianming Han |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Oncology China medicine.medical_specialty Genotype Single-nucleotide polymorphism Protein Serine-Threonine Kinases Polymorphism Single Nucleotide Young Adult 03 medical and health sciences 0302 clinical medicine Asian People Gene Frequency Internal medicine Drug Discovery Genetic model Odds Ratio Genetics Genetic predisposition medicine Humans SNP Genetic Predisposition to Disease Allele Molecular Biology Alleles Genetic Association Studies Genetics (clinical) business.industry Case-control study Odds ratio Middle Aged 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Schizophrenia Molecular Medicine Female business Biomarkers |
| Zdroj: | The Journal of Gene Medicine. 23 |
| ISSN: | 1521-2254 1099-498X |
| DOI: | 10.1002/jgm.3313 |
| Popis: | Background Schizophrenia (SZ) is a serious hereditary mental disease with a low recovery rate, especially due to the lack of understanding about the cause of the disease. VRK2 is considered to be related to the pathogenesis of schizophrenia. In this study, we analyzed the correlation between VRK2, rs4380187 single-nucleotide polymorphism (SNP), and schizophrenia. Methods Peripheral blood DNA was extracted using a genomic DNA extraction kit. The DNA samples were genotyped using the Agena MassARRAY platform, and four genetic models were applied to compute the odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression. The p value was obtained by the chi-square and t test for independent samples. Results The C allele of rs4380187 SNP was significantly (p = 0.008) associated with decreased risk of SZ. The AA genotype of rs4380187 showed significantly (p = 0.009) lower frequency in cases with SZ than in controls and was associated with decreased risk of the disease. The frequency of the CA genotype of rs4380187 correlated with a 0.73-fold decreased risk of SZ (p = 0.033). In the co-dominant genetic model, the genotype of rs4380187 was associated with a decreased risk of SZ (p = 0.010). We also found that the log-additive model of rs4380187 significantly reduced the risk of SZ disease (p = 0.007). Conclusion This study provides further evidence that rs4380187 SNP is associated with SZ. This genotype variation could be associated with the psychopathology and cognitive function in SZ. |
| Databáze: | OpenAIRE |
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