Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease
| Autor: | Twj Huizinga, Nomdo A.C. Westerdaal, F. G. J. Leppers–van de Straat, V. Keijsers, R. G. J. Westendorp, Matthijs Jansen, J.G.J. van de Winkel, W. L. van der Pol, MW van der Linden, Gestur Vidarsson |
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| Přispěvatelé: | Academic Medical Center, Landsteiner Laboratory |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Adolescent Genotype Neutrophils Biology Neisseria meningitidis medicine.disease_cause Meningococcal disease Phagocytosis medicine Immunology and Allergy Humans First-degree relatives Child Polymorphism Genetic Receptors IgG Chromosome Mapping Odds ratio medicine.disease Interleukin-10 Meningococcal Infections Interleukin 10 Infectious Diseases Chromosomes Human Pair 1 Immunology Gene polymorphism Meningitis Granulocytes |
| Zdroj: | Journal of infectious diseases, 184(12), 1548-1555. Oxford University Press |
| ISSN: | 0022-1899 |
| Popis: | The contribution of individual Fcgamma receptor (FcgammaR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcgammaR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcgammaR genotypes with disease. Efficient internalization of opsonized Neisseria meningitidis serogroup B was mediated via multiple FcgammaR subclasses on phagocytes. Accordingly, a low-efficiency combination of FcgammaRIIa-R/R131, FcgammaRIIIa-F/F158, and FcgammaRIIIb-NA2/2 genotypes was increased significantly in relatives of patients with MD, compared with healthy control subjects (P |
| Databáze: | OpenAIRE |
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