Cell Proliferation Kinetics in the Marginal Mucosa of Gastric Ulcer Evaluated by Immunostaining of DNA Polymerase α
| Autor: | Tomoko Kitajima, Masaru Okuhira, Arata Hiramatsu, Toshiaki Nakano, Takako Mizuno, Masanori Maruoka, Kyoichi Inoue |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty DNA polymerase medicine.drug_class Ranitidine Monoclonal antibody medicine Humans Stomach Ulcer Stage (cooking) Aged Staining and Labeling biology Cell growth Stomach digestive oral and skin physiology Gastroenterology Antibodies Monoclonal DNA Polymerase II Middle Aged Famotidine digestive system diseases Pathophysiology Kinetics medicine.anatomical_structure Gastric Mucosa Gastric pits biology.protein Female Cimetidine Cell Division Immunostaining |
| Zdroj: | Digestion. 48:185-191 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000200693 |
| Popis: | We studied the proliferative ability of the marginal mucosal cells surrounding the ulcer in the healing processes of gastric ulcers. We obtained a labeling index (LI) at the neck and generative zone of gastric pit using a monoclonal antibody against DNA polymerase alpha for tractable and intractable gastric ulcers located at the fundic mucosa during each endoscopic stage. The LI during the healing stage was higher than that during the active stage in both the tractable and intractable cases. However, in each stage, the LI of the tractable gastric ulcers was higher than that of their intractable counterparts. Finally, we analyzed the LI in tractable gastric ulcers after setting two groups: one treated with anti-ulcer drugs and the other untreated. There were no significant differences between these two groups. We believe that investigation of proliferative abilities in the marginal mucosa of gastric ulcers is important to understand the nature of gastric ulcers and to assess therapeutic efficacy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|