Upregulation of SERT and ADORA1 in broilers with acute right ventricular failure
| Autor: | Robert F. Wideman, James West, Mohammad Amir Karimi Torshizi, Mohammad Kamely |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hypertension Pulmonary 030204 cardiovascular system & hematology 03 medical and health sciences Adenosine A1 receptor 0302 clinical medicine Troponin T Downregulation and upregulation Internal medicine Gene expression medicine Animals Poultry Diseases Serotonin transporter Cyclic Nucleotide Phosphodiesterases Type 5 Heart Failure Serotonin Plasma Membrane Transport Proteins General Veterinary biology Receptor Adenosine A1 Myocardium medicine.disease Pulmonary hypertension Troponin Adenosine Up-Regulation 030104 developmental biology Endocrinology Gene Expression Regulation biology.protein Right ventricular failure Chickens medicine.drug |
| Zdroj: | Research in Veterinary Science. 125:397-400 |
| ISSN: | 0034-5288 |
| Popis: | Pulmonary hypertension (PH), remains a challenging disease with a large impact on both humans and meat-type chickens. PH is characterized by the onset of idiopathic pulmonary arterial hypertension leading to right ventricular failure. In this experiment relative gene expression of adenosine A1 receptor (ADORA1), serotonin transporter (SERT), phosphodiesterase 5A (PDE5) and troponin T2 were compared in hearts from broilers with acute right ventricular failure and from healthy birds. There were major increases in adenosine A1 receptor (177%) and serotonin transporter (475%), and more modest but significant increases in PDE5 (146%) and troponin T2 (140%) gene expressions in broilers with right ventricular failure compared to healthy birds (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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